PMID- 9067266
OWN - NLM
STAT- MEDLINE
DCOM- 19970409
LR  - 20041117
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 57
IP  - 6
DP  - 1997 Mar 15
TI  - Haplotype analysis defines a minimal interval for the multiple endocrine 
      neoplasia type 1 (MEN1) gene.
PG  - 1039-42
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized 
      by development of multiple endocrine tumors in affected individuals. The gene 
      responsible for the disease has been mapped to chromosome 11q13 by linkage 
      analysis, but the gene itself has not yet been identified. We allelotyped 33 
      affected individuals from an extensive MEN1 kindred using eight polymorphic 
      markers located on chromosome 11q13, including two new markers (D11S4907 and 
      D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of 
      affected individuals revealed two separate recombination events, providing new 
      centromeric and telomeric boundaries for the MEN1 gene. The present data indicate 
      the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 
      Mb region on chromosome 11q13.
FAU - Debelenko, L V
AU  - Debelenko LV
AD  - Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 
      20892, USA.
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Manickam, P
AU  - Manickam P
FAU - Kester, M
AU  - Kester M
FAU - Guru, S C
AU  - Guru SC
FAU - DiFranco, E M
AU  - DiFranco EM
FAU - Olufemi, S E
AU  - Olufemi SE
FAU - Agarwal, S
AU  - Agarwal S
FAU - Lubensky, I A
AU  - Lubensky IA
FAU - Zhuang, Z
AU  - Zhuang Z
FAU - Burns, A L
AU  - Burns AL
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Liotta, L A
AU  - Liotta LA
FAU - Collins, F S
AU  - Collins FS
FAU - Marx, S J
AU  - Marx SJ
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Alleles
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Genetic Markers
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Pedigree
MH  - Polymorphism, Genetic
MH  - Recombination, Genetic
EDAT- 1997/03/15 00:00
MHDA- 1997/03/15 00:01
CRDT- 1997/03/15 00:00
PHST- 1997/03/15 00:00 [pubmed]
PHST- 1997/03/15 00:01 [medline]
PHST- 1997/03/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1997 Mar 15;57(6):1039-42.