PMID- 9068166
OWN - NLM
STAT- MEDLINE
DCOM- 19970527
LR  - 20191024
IS  - 0161-3499 (Print)
IS  - 0161-3499 (Linking)
VI  - 26
IP  - 2
DP  - 1997 Mar-Apr
TI  - Preliminary investigations of pain and analgesia assessment in horses 
      administered phenylbutazone or placebo after arthroscopic surgery.
PG  - 150-5
AB  - Twenty-five horses undergoing arthroscopic surgery were studied to develop a 
      scheme for assessing pain in horses while investigating the effects of 
      phenylbutazone (PBZ) analgesia. Fifteen of the 25 horses received PBZ 4 mg/kg 
      intravenously (IV) before surgery and 2 mg/kg (IV) every 12 hours thereafter 
      until 60 hours; the remaining 10 (placebo group) were given a corresponding 
      volume of saline. In both groups, venous blood samples were collected for 
      catecholamine, beta-endorphin, and cortisol assays before premedication and up to 
      72 hours after surgery. Postoperative pain was evaluated by measuring predefined 
      behavioral and physiological variables. A total postoperative pain severity index 
      (TPPSI) was calculated using all variables. There were no differences between PBZ 
      and placebo groups in plasma beta-endorphin or catecholamine concentrations, but 
      the TPPSI was higher in the placebo group than in the PBZ group, suggesting that 
      perioperative treatment with PBZ has some analgesic benefit. This study shows the 
      difficulties associated with pain assessment in horses.
FAU - Raekallio, M
AU  - Raekallio M
AD  - Faculty of Veterinary Medicine, Department of Clinical Sciences, University of 
      Helsinki, Finland.
FAU - Taylor, P M
AU  - Taylor PM
FAU - Bennett, R C
AU  - Bennett RC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Vet Surg
JT  - Veterinary surgery : VS
JID - 8113214
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Catecholamines)
RN  - 60617-12-1 (beta-Endorphin)
RN  - GN5P7K3T8S (Phenylbutazone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Analgesia/*veterinary
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use
MH  - Arthroscopy/veterinary
MH  - Catecholamines/blood
MH  - Horse Diseases/*drug therapy
MH  - Horses/*surgery
MH  - Hydrocortisone/blood
MH  - Pain Measurement/*veterinary
MH  - Pain, Postoperative/drug therapy/*veterinary
MH  - Phenylbutazone/administration & dosage/*therapeutic use
MH  - Preanesthetic Medication
MH  - beta-Endorphin/blood
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0161349997000215 [pii]
AID - 10.1111/j.1532-950x.1997.tb01478.x [doi]
PST - ppublish
SO  - Vet Surg. 1997 Mar-Apr;26(2):150-5. doi: 10.1111/j.1532-950x.1997.tb01478.x.