PMID- 9070272
OWN - NLM
STAT- MEDLINE
DCOM- 19970417
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 231
IP  - 2
DP  - 1997 Feb 13
TI  - Vitamin D receptor alleles b, a, and T: risk factors for sporadic primary 
      hyperparathyroidism (HPT) but not HPT of uremia or MEN 1.
PG  - 329-32
AB  - Polymorphisms in the vitamin D receptor (VDR) gene have been hypothezised to 
      interfere with VDR expression. VDR alleles (Bb, Aa and Tt) were examined in 254 
      Caucasian patients with sporadic primary hyperparathyroidism (spHPT, n = 206), 
      HPT of multiple endocrine neoplasia type 1 (MEN-1; n = 17), and HPT of uremia (n 
      = 31). In comparison to age- and sex-matched controls, the b, a and T alleles 
      were overrepresented in 100 menopausal females with spHPT (p = 0.006-0.0004), 
      equivalent to an odds ratio of 2.6-3.4 for spHPT in homozygotes for the b, a and, 
      T alleles. The association between VDR genotypes and spHPT was restricted to 
      female patients and those with parathyroid adenoma (p = 0.0006-0.0001), whereas 
      HPT of MEN 1 and uremia seemed unrelated to the VDR polymorphisms (p = 
      0.26-0.96). The results suggest that the VDR alleles b, a, and T are novel risk 
      factors in the essentially uncharacterized pathogenesis of spHPT.
FAU - Carling, T
AU  - Carling T
AD  - Department of Surgery, Uppsala University Hospital, Sweden. 
      Tobias.Carling@kirurgi.uu.se
FAU - Kindmark, A
AU  - Kindmark A
FAU - Hellman, P
AU  - Hellman P
FAU - Holmberg, L
AU  - Holmberg L
FAU - Akerstrom, G
AU  - Akerstrom G
FAU - Rastad, J
AU  - Rastad J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - *Alleles
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/complications/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Polymorphism, Genetic
MH  - Prevalence
MH  - Receptors, Calcitriol/*genetics
MH  - Risk Factors
MH  - Uremia/*complications
EDAT- 1997/02/13 00:00
MHDA- 1997/02/13 00:01
CRDT- 1997/02/13 00:00
PHST- 1997/02/13 00:00 [pubmed]
PHST- 1997/02/13 00:01 [medline]
PHST- 1997/02/13 00:00 [entrez]
AID - S0006-291X(97)96086-1 [pii]
AID - 10.1006/bbrc.1997.6086 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1997 Feb 13;231(2):329-32. doi: 
      10.1006/bbrc.1997.6086.