PMID- 9072315
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20191101
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Correlation analysis of blood pressure and platelet aggregation/vascular 
      reactivity in SHRSP, WKY, F1 and backcross generations.
PG  - S107-8
AB  - 1. Hypofunction of stroke-prone spontaneously hypertensive rat (SHRSP) platelets 
      at developmental ages of hypertension is due to the defective protein (p47) 
      phosphorylation which is mediated by protein kinase C. This study was undertaken 
      to examine the genetic association of platelet functions and vascular reactivity 
      with hypertension using male WKY, SHRSP, F1 and backcross generations at 16-18 
      weeks of age. 2. The distribution of blood pressure was continuous in each 
      generation. 3. Contraction of mesenteric vascular bed with norepinephrine was 
      positively correlated with blood pressure in the five generations (r = 0.77, n = 
      128). 4. Thrombin-induced platelet aggregation was inversely correlated with 
      blood pressure (r = -0.87, n = 127). 5. The distribution of platelet aggregation 
      and contraction was continuous in each generation, and backcross generations were 
      not likely to have 1:1 segregation. 6. These results suggest the possibility that 
      platelet hypoaggregability and peripheral vascular resistance are due to the 
      pleiotropic effect of hypertensive genes, or that genes controlling these three 
      characters are closely linked each other.
FAU - Hamano, M
AU  - Hamano M
AD  - University of Shizuoka, School of Pharmaceutical Sciences, Japan.
FAU - Mashiko, S
AU  - Mashiko S
FAU - Onda, T
AU  - Onda T
FAU - Tomita, I
AU  - Tomita I
FAU - Tomita, T
AU  - Tomita T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Cerebrovascular Disorders/genetics/physiopathology
MH  - Female
MH  - Hypertension/*genetics/*physiopathology
MH  - Male
MH  - Platelet Aggregation/*drug effects
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Splanchnic Circulation/drug effects
MH  - Vascular Resistance/*drug effects
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02841.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S107-8. doi: 
      10.1111/j.1440-1681.1995.tb02841.x.