PMID- 9072350
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20191101
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Augmented expression of the endothelin-A receptor gene in cultured mesangial 
      cells from stroke-prone spontaneously hypertensive rats.
PG  - S191-2
AB  - 1. To elucidate the role of endothelin (ET) receptor in hypertension, we studied 
      the expression of the ET-A receptor (ET-AR) gene and the ET-B receptor (ET-BR) 
      gene in cultured mesangial cells isolated from stroke-prone spontaneously 
      hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats. 2. The mesangial cells 
      from both SHRSP and WKY expressed ET-AR predominantly. The level of the ET-AR 
      mRNA in mesangial cells from SHRSP was 5-fold higher than that in the cells from 
      WKY. The ET-BR mRNA in the mesangial cells from both strains was hardly 
      detectable by northern blot analysis. 3. These results demonstrate that the 
      expression of the ET-AR gene was markedly augmented in mesangial cells from 
      SHRSP.
FAU - Hiraoka, J
AU  - Hiraoka J
AD  - Graduate School of Human and Environmental Studies, Kyoto University, Japan.
FAU - Arai, H
AU  - Arai H
FAU - Yoshimasa, T
AU  - Yoshimasa T
FAU - Takaya, K
AU  - Takaya K
FAU - Miyamoto, Y
AU  - Miyamoto Y
FAU - Yamashita, J
AU  - Yamashita J
FAU - Suga, S
AU  - Suga S
FAU - Ogawa, Y
AU  - Ogawa Y
FAU - Shirakami, G
AU  - Shirakami G
FAU - Itoh, H
AU  - Itoh H
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
RN  - 0 (Receptors, Endothelin)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Cells, Cultured
MH  - Cerebrovascular Disorders/genetics/physiopathology
MH  - Glomerular Mesangium/*metabolism
MH  - Hypertension/genetics/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Receptors, Endothelin/*biosynthesis/*genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02876.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S191-2. doi: 
      10.1111/j.1440-1681.1995.tb02876.x.