PMID- 9072380
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20220310
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Animal models of vascular dementia with emphasis on stroke-prone spontaneously 
      hypertensive rats.
PG  - S257-9
AB  - 1. Two experimental models designed to reflect different aspects of vascular 
      dementia (rats with cerebrovascular occlusion and rats with cerebral 
      embolization) and stroke-prone spontaneously hypertensive rats (SHRSP) have been 
      evaluated. The focus was on SHRSP as a model for vascular dementia. 2. 
      Neuropathological data revealed that the cerebrovascular disorder in SHRSP was 
      associated with lesions in their brains similar to those seen in typical human 
      cases of multiple cerebral infarction. 3. SHRSP that died from cerebral 
      infarction exhibited behavioural changes, including increased activity and 
      disrupted circadian rhythms, which might correspond to the state of delirium 
      observed in patients with dementia. 4. SHRSP displayed cognitive impairments in a 
      step-through passive avoidance task. 5. When compared to age-matched Wistar Kyoto 
      (WKY) rats, both conscious and anaesthetized SHRSP had significantly decreased 
      cerebral spinal fluid (CSF) levels of acetylcholine (ACh). 6. These findings 
      suggest that the SHRSP might serve as a suitable animal model for vascular 
      dementia in humans caused by cerebrovascular lesions.
FAU - Saito, H
AU  - Saito H
AD  - First Department of Pharmacology, Hokkaido University School of Medicine, 
      Sapporo, Japan.
FAU - Togashi, H
AU  - Togashi H
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Nakamura, N
AU  - Nakamura N
FAU - Minami, M
AU  - Minami M
FAU - Parvez, H
AU  - Parvez H
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Cerebral Arteries/physiology
MH  - Cerebrovascular Disorders/genetics/physiopathology
MH  - Cognition/physiology
MH  - Dementia, Vascular/*physiopathology/psychology
MH  - Disease Models, Animal
MH  - Intracranial Embolism and Thrombosis/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02906.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S257-9. doi: 
      10.1111/j.1440-1681.1995.tb02906.x.