PMID- 9072383
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20191101
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Increased immunoreactivities for the basic fibroblast growth factor and its 
      receptor in astrocytes at the site of cerebral lesions and oedematous change in 
      SHR.
PG  - S262-4
AB  - 1. To obtain information about changes of basic fibroblast growth factor (bFGF) 
      in the brain in chronic hypertension, we immunohistochemically studied the 
      distribution and level of bFGF and its receptor in the brain of stroke-prone 
      spontaneously hypertensive rats (SHRSP). 2. In the control normotensive rats, 
      immunoreactivity for bFGF was demonstrated in nerve cells, while there was almost 
      no reactivity in astrocytes. 3. In SHRSP, there was a marked immunoreactivity in 
      the densely accumulated reactive cells, particularly astrocytes, in and around 
      cerebral cortical lesions. Slightly increased reaction for bFGF was found in the 
      nerve cells around lesions. Astrocytes in the subcortical white matter on both 
      ipsi- and contralateral sides of the cortical lesion also showed immunoreactivity 
      for bFGF. The location of increased bFGF expression in SHRSP corresponded very 
      well with the site of extravasated plasma fluid demonstrated by anti-fibrinogen 
      antibody. Electron microscopically, bFGF was shown in astrocytes along the rough 
      endoplasmic reticulum suggesting the growth factor to be produced in the cells 
      and not to be taken up from the surroundings. Expression of FGF-receptor was also 
      demonstrated in reactive astrocytes in the oedematous cortical portion around 
      lesion and in the oedematous subcortical white matter. 4. These findings indicate 
      the possibility that oedema and the simultaneously generated free radicals or 
      some extravasated plasma components express bFGF in astrocytes and probably in 
      nerve cells as well as FGF-receptor in astrocytes, and that the thus expressed 
      bFGF and its receptor play some role in the sequence of developmental events of 
      hypertensive cerebral lesions.
FAU - Kataoka, H
AU  - Kataoka H
AD  - Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
FAU - Yamada, E
AU  - Yamada E
FAU - Hayase, Y
AU  - Hayase Y
FAU - Hazama, F
AU  - Hazama F
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - Brain/*pathology
MH  - Brain Edema/*pathology
MH  - Cerebrovascular Disorders/genetics/physiopathology
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Receptors, Fibroblast Growth Factor/*metabolism
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02909.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S262-4. doi: 
      10.1111/j.1440-1681.1995.tb02909.x.