PMID- 9072421
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20211203
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Protective effects of manidipine on spermatogenesis in stroke-prone spontaneously 
      hypertensive rats.
PG  - S342-4
AB  - 1. We evaluated the protective effects of manidipine on spermatogenic damage 
      induced by the hypertensive vascular changes in stroke-prone spontaneously 
      hypertensive rats (SHRSP). 2. Blood pressure reached more than 250 mmHg in SHRSP 
      at 15 weeks of age, and thereafter the hypertensive changes in testicular 
      arterioles developed. Manidipine reduced both the blood pressure and the 
      hypertensive vascular changes. 3. Although immature and mature spermatids greatly 
      diminished in SHRSP at 23 weeks of age, manidipine could preserve almost normal 
      spermatogenesis even at 23 weeks of age. Transferrin concentration in testicular 
      cytosol, which was considered to be indicative of the Sertoli cell function, in 
      SHRSP with manidipine administration was significantly higher than that in SHRSP 
      with no treatment at 23 weeks of age. 4. In conclusion, manidipine could prevent 
      the development of the hypertensive changes in intratesticular arterioles and 
      maintain normal Sertoli cell function. As a result, manidipine protected 
      spermatogenic damage in SHRSP.
FAU - Akagashi, K
AU  - Akagashi K
AD  - Department of Urology, Sapporo Medical University, School of Medicine, Japan.
FAU - Itoh, N
AU  - Itoh N
FAU - Kumamoto, Y
AU  - Kumamoto Y
FAU - Tsukamoto, T
AU  - Tsukamoto T
FAU - Suzuki, T
AU  - Suzuki T
FAU - Ohta, Y
AU  - Ohta Y
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Dihydropyridines)
RN  - 0 (Nitrobenzenes)
RN  - 0 (Piperazines)
RN  - 6O4754US88 (manidipine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Calcium Channel Blockers/*pharmacology
MH  - Cerebrovascular Disorders/genetics/physiopathology
MH  - Cytosol/drug effects/metabolism
MH  - Dihydropyridines/*pharmacology
MH  - Hypertension/pathology/physiopathology
MH  - Male
MH  - Nitrobenzenes
MH  - Piperazines
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Regional Blood Flow/drug effects
MH  - Spermatogenesis/*drug effects
MH  - Testis/blood supply/drug effects/pathology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02947.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S342-4. doi: 
      10.1111/j.1440-1681.1995.tb02947.x.