PMID- 9072449
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20191101
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Role of cerebral ATP-sensitive K+ channels in arterial pressure regulation during 
      acute cerebral ischaemia in SHR and WKY rats.
PG  - S70-2
AB  - 1. ATP-sensitive K+ channels (KATP) are activated either by decreased 
      intracellular ATP content or ATP/ADP ratio during ischaemia. We examined the role 
      of a cerebral KATP in arterial pressure regulation during acute cerebral 
      ischaemia using SHR and WKY rats. Thirteen week old male SHR or WKY rats were 
      anaesthetized with urethane, and arterial pressure and heart rate were recorded 
      under an artificial ventilation. 2. Intracerebroventricular (i.c.v.) injections 
      of glibenclamide, a specific inhibitor of KATP, elicited dose-dependent 
      vasopressor responses in WKY with bilateral ligation of carotid arteries, whereas 
      it caused smaller vasopressor responses in SHR than WKY. 3. Systemic 
      administration of AVP V1 receptor antagonist, OPC-21268, abolished the 
      vasopressor responses of i.c.v. injections of glibenclamide in WKY but not in 
      SHR. 4. Intracerebroventricular injections of glibenclamide caused both the 
      increase in plasma concentration of AVP and the decrease in pituitary AVP content 
      in WKY with bilateral ligation of carotid arteries, whereas it elicited no 
      significant change in plasma and pituitary concentration of AVP in SHR with 
      bilateral ligation of carotid arteries. 5. Cerebral KATP may play a role in the 
      protection of excess hypertension by inhibiting AVP release from the pituitary 
      glands during acute ischaemia in WKY, but this mechanism might not work in SHR 
      during acute cerebral ischaemia.
FAU - Nishimura, M
AU  - Nishimura M
AD  - Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of 
      Medicine, Kajii-cho, Kawaramachi-Hirokoji, Japan.
FAU - Nanbu, A
AU  - Nanbu A
FAU - Sakamoto, M
AU  - Sakamoto M
FAU - Nakanishi, T
AU  - Nakanishi T
FAU - Takahashi, H
AU  - Takahashi H
FAU - Yoshimura, M
AU  - Yoshimura M
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
RN  - 0 (Antidiuretic Hormone Receptor Antagonists)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Piperidines)
RN  - 0 (Potassium Channels)
RN  - 0 (Quinolones)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 131631-89-5 (OPC 21268)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - SX6K58TVWC (Glyburide)
SB  - IM
MH  - Adenosine Triphosphate/*physiology
MH  - Animals
MH  - Antidiuretic Hormone Receptor Antagonists
MH  - Arginine Vasopressin/metabolism
MH  - Blood Pressure/*drug effects
MH  - Brain Chemistry/drug effects/*physiology
MH  - Brain Ischemia/*physiopathology
MH  - Glyburide/administration & dosage/pharmacology
MH  - Hypoglycemic Agents/administration & dosage/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Piperidines/pharmacology
MH  - Pituitary Gland/drug effects/metabolism
MH  - Potassium Channels/drug effects/*physiology
MH  - Quinolones/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02975.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S70-2. doi: 
      10.1111/j.1440-1681.1995.tb02975.x.