PMID- 9072453
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20191101
IS  - 0143-9294 (Print)
IS  - 0143-9294 (Linking)
VI  - 22
IP  - 1
DP  - 1995 Dec
TI  - Age-related changes in cerebral and peripheral monoamine contents in stroke-prone 
      spontaneously hypertensive rats.
PG  - S80-2
AB  - 1. We examined monoamine contents in various regions of the brain and 
      catecholamine contents in the heart and the adrenal gland of stroke-prone 
      spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats aged 1.5, 3 
      and 6 months. 2. The noradrenaline (NA) content and the 5-hydroxytryptamine 
      (5-HT) content in the brainstem were larger in 1.5 month old SHRSP than in the 
      age-matched WKY. In addition, at age 6 months the brainstem 5-HT content was 
      higher in SHRSP than in WKY. 3. The NA and 5-HT contents in basal ganglia, 
      thalamus, hypothalamus, septum and anterior and lateral cerebral cortex showed no 
      significant difference between SHRSP and WKY at any age. 4. The dopamine (DA) 
      contents in all brain regions examined did not differ between WKY and SHRSP at 
      any age. 5. The NA contents in left and right ventricles were larger in 3 month 
      old SHRSP than in the age-matched WKY, but were lower in 6 month old SHRSP than 
      in the age-matched WKY. The cardiac DA contents did not differ between the two 
      rat strains of any age. 6. The adrenal NA and adrenaline (A) contents in 6 month 
      old SHRSP were significantly larger than those in the corresponding WKY. 7. These 
      findings suggest that the increased NA and 5-HT contents in the brainstem may be 
      related to the onset of hypertension, and that the altered cardiac NA contents 
      and adrenal NA and A contents change as a result of the onset or persistence of 
      hypertension.
FAU - Uchida, T
AU  - Uchida T
AD  - Department of Pharmacology, Kinki University School of Medicine, Osaka-Sayama, 
      Japan.
FAU - Nishimura, Y
AU  - Nishimura Y
FAU - Suzuki, A
AU  - Suzuki A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol Suppl
JT  - Clinical and experimental pharmacology & physiology. Supplement
JID - 7611484
RN  - 0 (Biogenic Monoamines)
SB  - IM
MH  - Adrenal Glands/*metabolism
MH  - Aging/*metabolism
MH  - Animals
MH  - Biogenic Monoamines/*metabolism
MH  - Brain Chemistry/*physiology
MH  - Brain Stem/metabolism
MH  - Cerebrovascular Disorders/genetics/physiopathology
MH  - Heart Ventricles/metabolism
MH  - Myocardium/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02979.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S80-2. doi: 
      10.1111/j.1440-1681.1995.tb02979.x.