PMID- 9073002
OWN - NLM
STAT- MEDLINE
DCOM- 19970603
LR  - 20151119
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 10
IP  - 3
DP  - 1997 Mar
TI  - Effect of inhaled beclomethasone dipropionate on isocapnic hyperventilation with 
      cold air in asthmatics, measured with forced oscillation technique.
PG  - 665-71
AB  - Isocapnic hyperventilation with cold air (IHCA) is a reliable technique for 
      assessing indirect bronchial hyperresponsiveness in patients with asthma. 
      Impedance measurement of the respiratory system by the forced pseudorandom noise 
      oscillation technique is a sensitive technique to assess changes in bronchial 
      tone after IHCA. The aim of this study was to evaluate the effect of 6 weeks of 
      treatment with beclomethasone dipropionate, 1,000 microg x day-1, on IHCA in 
      asthmatic patients, measured with both forced oscillation technique and 
      flow-volume recordings. Forty patients with mild asthma were included in this 
      double-blind, placebo-controlled parallel-group study. Stratification on the 
      basis of sex was performed to overcome differences in airway diameter. At entry 
      and every 2 weeks during the treatment period, IHCA was performed and patient 
      diaries were evaluated. Characteristic changes in forced oscillation parameters 
      after IHCA were observed in all patients. After 6 weeks of treatment, BDP-treated 
      patients showed statistically significant differences in impedance measurements 
      after IHCA, manifested by significant attenuation of resistance at 8 Hz (p<0.01), 
      slope of the frequency-resistance curve (p<0.01), reactance at 8 Hz (p=0.01), and 
      resonant frequency (f0) (p<0.02). Flow-volume recordings showed only a 
      statistically significant change in the decrease of inspiratory vital capacity 
      (IVC) (p=0.01). Furthermore, a significant correlation was observed between serum 
      immunoglobulin E (IgE) levels and the effect of BDP on IHCA, measured with forced 
      oscillation technique. In this study, beclomethasone dipropionate, 1,000 microg x 
      day(-1) for 6 weeks, decreased indirect bronchial hyperresponsiveness as assessed 
      by cold air bronchoprovocation in asthmatic patients. The forced oscillation 
      technique proved a more sensitive method of detecting changes in bronchial tone 
      than flow-volume recordings.
FAU - Pennings, H J
AU  - Pennings HJ
AD  - Dept of Pulmonology, University Hospital Maastricht, The Netherlands.
FAU - Wouters, E F
AU  - Wouters EF
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Anti-Asthmatic Agents)
RN  - KGZ1SLC28Z (Beclomethasone)
SB  - IM
MH  - Adult
MH  - Airway Resistance/drug effects
MH  - Anti-Asthmatic Agents/*administration & dosage/therapeutic use
MH  - Asthma/diagnosis/*drug therapy/*physiopathology
MH  - Beclomethasone/*administration & dosage/therapeutic use
MH  - Bronchial Hyperreactivity/*drug therapy/etiology/physiopathology
MH  - Bronchial Provocation Tests
MH  - Cold Temperature
MH  - Double-Blind Method
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Peak Expiratory Flow Rate
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1997 Mar;10(3):665-71.