PMID- 9073568
OWN - NLM
STAT- MEDLINE
DCOM- 19970501
LR  - 20220318
IS  - 0022-4804 (Print)
IS  - 0022-4804 (Linking)
VI  - 67
IP  - 2
DP  - 1997 Feb 1
TI  - Differential effects of IL-1 beta and ibuprofen after endotoxic challenge in 
      mice.
PG  - 199-204
AB  - Interleukin-1 (IL-1) and ibuprofen modulate the host response in different models 
      after endotoxic challenge. A comparative study was made between the two drugs, as 
      they were jointly administered, to explore a potentiation of their therapeutic 
      effects. Endotoxic challenge was provoked in CBA/H mice with lipopolysaccharide 
      (LPS) from Escherichia coli (125 mg/kg), with administration of recombinant 
      murine IL-1 beta (80 ng/mouse) 24 hr pre-LPS. Two doses of ibuprofen (1 mg/kg) 
      were administered 1 hr before and 30 min after the septic challenge. Serum levels 
      of IL-1 alpha, tumor necrosis factor-alpha (TNF alpha), and interleukin-6 (IL-6) 
      were determined 1,2, and 4 hr, post-LPS, and prostaglandin E2 (PGE2) urine levels 
      4,8, and 12 hr post-LPS, and a comparative mortality study was performed. IL-1 
      beta treatment provoked a reduction of IL-1 alpha, TNF alpha, and IL-6 without 
      affecting PGE2, while ibuprofen provoked a later increase of IL-1 alpha, TNF 
      alpha, and IL-6, with a decrease of PGE2. Both drugs caused a notable enhancement 
      of survival, with no difference between them, but their combined administration 
      caused no improvement. We conclude that both drugs exert a similar therapeutic 
      effect in endotoxic shock by different mechanisms.
FAU - Mansilla-Rosello, A
AU  - Mansilla-Rosello A
AD  - Experimental Surgery Unit, Virgen de las Nieves Foundation, Granada, Spain.
FAU - Ferron-Orihuela, J A
AU  - Ferron-Orihuela JA
FAU - Ruiz-Cabello, F
AU  - Ruiz-Cabello F
FAU - Garrote-Lara, D
AU  - Garrote-Lara D
FAU - Fernandez-Mondejar, E
AU  - Fernandez-Mondejar E
FAU - Delgado-Carrasco, M L
AU  - Delgado-Carrasco ML
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacology
MH  - Dinoprostone/urine
MH  - Drug Interactions
MH  - Female
MH  - Ibuprofen/administration & dosage/*pharmacology
MH  - Interleukin-1/administration & dosage/blood/*pharmacology
MH  - Interleukin-6/blood
MH  - Lipopolysaccharides/*toxicity
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Shock, Septic/*drug therapy/immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - S0022-4804(96)94982-3 [pii]
AID - 10.1006/jsre.1996.4982 [doi]
PST - ppublish
SO  - J Surg Res. 1997 Feb 1;67(2):199-204. doi: 10.1006/jsre.1996.4982.