PMID- 9074412
OWN - NLM
STAT- MEDLINE
DCOM- 19970507
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 96
IP  - 4
DP  - 1997 Mar
TI  - Relationship of T leukaemias with cerebriform nuclei to T-prolymphocytic 
      leukaemia: a cytogenetic analysis with in situ hybridization.
PG  - 724-32
AB  - Sezary cell leukaemia (SCL) is a mature T-cell leukaemia with characteristic 
      cerebriform nuclei, whereas Sezary syndrome (SS) involves a mature T-cell 
      lymphoma with a similar nuclear morphology. We have examined these diseases by 
      cytogenetics chromosome painting and fluorescence in situ hybridization (FISH). 
      Both diseases had complex cytogenetic abnormalities. All three cases of SCL 
      investigated had inv(14)(q11:q32) and two had iso(8q). No case of SS had these 
      abnormalities but, instead, iso(17q) or 17p+ was present in the three cases of SS 
      investigated and FISH indicated loss of heterozygosity due to deletion of a 
      region at 17p 13 that included the tumour suppressor gene P53, implicating it in 
      this malignancy. One case of SCL had iso(17q). The abnormalities of chromosomes 8 
      and 14 in SCL are commonly observed in T-prolymphocytic leukaemia (T-PLL) and 
      suggest that SCL may be a variant of T-PLL rather than of SS.
FAU - Brito-Babapulle, V
AU  - Brito-Babapulle V
AD  - Royal Marsden Hospital, London.
FAU - Maljaie, S H
AU  - Maljaie SH
FAU - Matutes, E
AU  - Matutes E
FAU - Hedges, M
AU  - Hedges M
FAU - Yuille, M
AU  - Yuille M
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Prolymphocytic/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Sezary Syndrome/*genetics/pathology
MH  - Skin Neoplasms/*genetics/pathology
MH  - Translocation, Genetic
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1046/j.1365-2141.1997.9702605.x [doi]
PST - ppublish
SO  - Br J Haematol. 1997 Mar;96(4):724-32. doi: 10.1046/j.1365-2141.1997.9702605.x.