PMID- 9074779
OWN - NLM
STAT- MEDLINE
DCOM- 19970527
LR  - 20181130
IS  - 0066-4278 (Print)
IS  - 0066-4278 (Linking)
VI  - 59
DP  - 1997
TI  - Osmoreceptors in the central nervous system.
PG  - 601-19
AB  - Osmoreceptors regulate sodium and water balance in a manner that maintains the 
      osmotic pressure of the extracellular fluid (ECF) near an ideal set point. In 
      rats, the concerted release of oxytocin and vasopressin, which is determined by 
      the firing rate of magnocellular neurosecretory cells (MNCs), plays a key role in 
      osmoregulation through the effects of natriuresis and diuresis. Changes in 
      excitatory synaptic drive, derived from osmosensitive neurons in the organum 
      vasculosum lamina terminalis (OVLT), combine with endogenously generated 
      osmoreceptor potentials to modulate the firing rate of MNCs. The cellular basis 
      for osmoreceptor potentials has been characterized using patch-clamp recordings 
      and morphometric analysis in MNCs isolated from the supraoptic nucleus of the 
      adult rat. In these cells, stretch-inactivated cationic channels transduce 
      osmotically evoked changes in cell volume into functionally relevant changes in 
      membrane potential. The experimental details of these mechanisms are reviewed in 
      their physiological context.
FAU - Bourque, C W
AU  - Bourque CW
AD  - Centre for Research in Neuroscience, Montreal General Hospital, Canada.
FAU - Oliet, S H
AU  - Oliet SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Physiol
JT  - Annual review of physiology
JID - 0370600
RN  - 0 (Hormones)
RN  - 0 (Ion Channels)
SB  - IM
MH  - Animals
MH  - Central Nervous System/*metabolism
MH  - Hormones/metabolism
MH  - Humans
MH  - Hypothalamus/cytology/physiology
MH  - Ion Channels/physiology
MH  - Neurosecretory Systems/cytology/physiology
MH  - Osmosis
MH  - Pituitary Gland, Posterior/metabolism
MH  - *Water-Electrolyte Balance/physiology
RF  - 98
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1146/annurev.physiol.59.1.601 [doi]
PST - ppublish
SO  - Annu Rev Physiol. 1997;59:601-19. doi: 10.1146/annurev.physiol.59.1.601.