PMID- 9076407
OWN - NLM
STAT- MEDLINE
DCOM- 19970523
LR  - 20191101
IS  - 0954-3007 (Print)
IS  - 0954-3007 (Linking)
VI  - 51
IP  - 3
DP  - 1997 Mar
TI  - The effect of increased egg consumption on plasma cholesteryl ester transfer 
      activity in healthy subjects.
PG  - 172-6
AB  - BACKGROUND: Plasma cholesteryl ester transfer activity influences the 
      distribution of cholesterol among plasma lipoproteins and changes in its 
      activities may influence the response of plasma lipoprotein cholesterol levels to 
      increased cholesterol intake in the form of eggs. OBJECTIVE: The aim of the study 
      was to determine the effect of increased egg intake on plasma newly synthesized 
      cholesteryl ester transfer (NCET) activity and plasma lipids and lipoprotein 
      levels in free-living men and women. DESIGN: The study was longitudinal and 
      included a 12 d intervention arm and a similar control period immediately prior 
      to the intervention to account for any changes in variables with time. SUBJECTS: 
      Thirty two healthy subjects aged 20-57 y and consuming self-selected diets were 
      recruited. Twelve men and 14 women were entered into the intervention arm of the 
      study. Twelve of these subjects and six others were in the control group. 
      INTERVENTIONS: Subjects who participated in the intervention phase received one 
      additional egg per day. RESULTS: Plasma NCET activity decreased significantly (P 
      = 0.05) in the 26 subjects who consumed an extra egg, mainly due to a significant 
      (P = 0.02) decrease (-13.4%) in the activity in the women. Plasma cholesterol and 
      apolipoprotein B-containing lipoprotein cholesterol increased significantly (P < 
      0.05) in the intervention group and in men (P = 0.02) but not in women. Age was 
      correlated significantly (r = 0.519, P < 0.01) with the change in plasma NCET 
      activity in all subjects and in men (r = -0.644, P < 0.05). The decrease in 
      plasma NCET activity was significantly (P = 0.02) less in the lowest tertile 
      compared with other tertiles of self-reported habitual dietary cholesterol intake 
      independent of age and gender. CONCLUSIONS: These data suggest that an increase 
      in dietary cholesterol reduces plasma NCET activity particularly in women and 
      older men and individuals with higher habitual intakes of cholesterol. 
      Furthermore, a reduction in plasma NCET activity may tend to limit the increase 
      in apoB-containing lipoprotein cholesterol in women during increased egg 
      consumption.
FAU - Sutherland, W H
AU  - Sutherland WH
AD  - Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
FAU - Ball, M J
AU  - Ball MJ
FAU - Walker, H
AU  - Walker H
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (CETP protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycoproteins)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Carrier Proteins/blood/*drug effects/*metabolism
MH  - Cholesterol Ester Transfer Proteins
MH  - Cholesterol, Dietary/administration & dosage/*pharmacology
MH  - Cholesterol, LDL/blood
MH  - *Eggs
MH  - Female
MH  - *Glycoproteins
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1038/sj.ejcn.1600379 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 1997 Mar;51(3):172-6. doi: 10.1038/sj.ejcn.1600379.