PMID- 9078285
OWN - NLM
STAT- MEDLINE
DCOM- 19970410
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 94
IP  - 1
DP  - 1997 Mar
TI  - Acute lymphoblastic leukemia and chromosome 21.
PG  - 8-12
AB  - A short review of chromosome 21 abnormalities in acute lymphoblastic leukemia 
      (ALL) is presented. Trisomy and polysomy 21 are nonrandom anomalies that are 
      frequently observed in ALL. Their occurrence, although not specific, as well as 
      the high incidence of acute leukemia in subjects with constitutional trisomy 21, 
      suggests that chromosome 21 plays a particular role in leukemogenesis. More 
      specific to ALL, t(12;21)(p13;q22), resulting in a fusion TEL-AML1, gene has 
      recently been shown to be the most frequent translocation in childhood B-cell 
      lineage ALL (20-30% of cases). In addition, the importance of analysis of marker 
      chromosomes with fluorescence in situ hybridization (FISH) techniques is 
      underscored as partial amplifications or rearrangements of chromosome 21 may be 
      implicated.
FAU - Berger, R
AU  - Berger R
AD  - Institute of Molecular Genetics, INSERM/CNRS, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Genetic Markers)
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Down Syndrome
MH  - Genetic Markers
MH  - Humans
MH  - Mosaicism
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Translocation, Genetic
RF  - 73
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0165460896003512 [pii]
AID - 10.1016/s0165-4608(96)00351-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Mar;94(1):8-12. doi: 10.1016/s0165-4608(96)00351-2.