PMID- 9078288
OWN - NLM
STAT- MEDLINE
DCOM- 19970410
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 94
IP  - 1
DP  - 1997 Mar
TI  - Genetic abnormalities in chronic lymphocytic leukemia and their clinical and 
      prognostic implications.
PG  - 27-35
AB  - Clonal chromosome abnormalities can be detected in approximately 50% of patients 
      with chronic lymphocytic leukemia (CLL). The most common changes are trisomy 12, 
      followed by structural abnormalities of 13q, 11q, 6q, and 14q. By fluorescence in 
      situ hybridization (FISH), these aberrations can be demonstrated even in cases 
      with insufficient mitotic yield or a normal karyotype. The biologic consequences 
      of trisomy 12 are unknown, but a gene dosage effect is suspected and studies on 
      partial trisomy 12 indicate that the region 12q13 to 12q22 might be of particular 
      pathogenetic importance. Trisomy 12 is strongly associated with atypical 
      lymphocyte morphology and seems to be a secondary event in leukemogenesis, as 
      shown by combined immunophenotyping and interphase FISH. Structural abnormalities 
      of 13q frequently involve hetero- and homozygous deletions of a region in 13q14, 
      distal to the retinoblastoma gene, which may be the site of a tumor suppressor 
      gene. In contrast to a normal karyotype or structural changes of 13q, complex 
      karyotypic abnormalities, high percentage of abnormal metaphases, trisomy 12 and 
      structural changes involving the P53 tumor suppressor gene on 17p13 are adverse 
      prognostic indicators. Cytogenetic and molecular findings provide important 
      diagnostic, clinical, and prognostic information which can contribute to 
      treatment decisions and follow-up of CLL patients.
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Center for Human Genetics, University of Leuven, Belgium.
FAU - Michaux, L
AU  - Michaux L
FAU - Criel, A
AU  - Criel A
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Van den Berghe, H
AU  - Van den Berghe H
FAU - Hossfeld, D K
AU  - Hossfeld DK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Genes, p53/genetics
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Prognosis
MH  - Trisomy/*genetics
RF  - 84
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0165460896002464 [pii]
AID - 10.1016/s0165-4608(96)00246-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Mar;94(1):27-35. doi: 10.1016/s0165-4608(96)00246-4.