PMID- 9078290
OWN - NLM
STAT- MEDLINE
DCOM- 19970410
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 94
IP  - 1
DP  - 1997 Mar
TI  - Genes and chromosomes in chronic B-cell leukemia.
PG  - 44-51
AB  - Cytogenetic analysis of patients with chronic B-cell leukemia (B-CLL) indicates 
      that 50% have chromosome abnormalities, while fluorescence in situ hybridization 
      (FISH) and molecular techniques reveal an even higher incidence. Trisomy 12 and 
      deletions or translocation of chromosome 13q14 are the most common abnormalities, 
      but in neither case has the gene or genes involved in the abnormalities been 
      identified. Combined FISH and immunophenotyping studies suggest that both 
      abnormalities are secondary events in B-CLL. Other recurring chromosome 
      abnormalities include 6q-, 11q- and 12p-, but the genes involved in these 
      abnormalities have not been identified. Involvement of the BCL1, BCL2, and BCL3 
      genes has been reported, but the numbers are low and the cases tend to be 
      atypical. Trisomy 12 in association with complex karyotypic abnormalities is 
      associated with a poor prognosis, and FISH studies show a strong correlation 
      between trisomy 12, atypical morphology, and advanced disease. Ten to 15% of 
      patients have mutations of p53 which is associated with advanced disease, 
      resistance to treatment, and poor survival.
FAU - Crossen, P E
AU  - Crossen PE
AD  - Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Deletion
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Gene Rearrangement
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Prognosis
MH  - Proto-Oncogenes/genetics
MH  - Trisomy/genetics
RF  - 104
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0165460896002531 [pii]
AID - 10.1016/s0165-4608(96)00253-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Mar;94(1):44-51. doi: 10.1016/s0165-4608(96)00253-1.