PMID- 9078587
OWN - NLM
STAT- MEDLINE
DCOM- 19970512
LR  - 20061115
IS  - 0188-4409 (Print)
IS  - 0188-4409 (Linking)
VI  - 28
IP  - 1
DP  - 1997 Spring
TI  - Vaccination of different strains of mice against cutaneous leishmaniosis: 
      usefulness of membrane antigens encapsulated into liposomes by intraperitoneal 
      and subcutaneous administration.
PG  - 47-53
AB  - The objective of this study was to assess the usefulness of parasite-surface 
      molecules reconstituted into liposomes to vaccinate four different strains of 
      mice (C57BL/10, CBA/ca, C57BL/6 and NZB) with different levels of susceptibility 
      to L. m. mexicana infection and to find out possible increases in specific 
      antibody response after vaccination, but before infection with virulent 
      promastigotes. Mice were vaccinated with parasite membrane antigens incorporated 
      into liposomes and antibody levels were recorded. Vaccination was effective to 
      protect CBA/ca and C57BL/6 but not C57BL/10 mice and NZB animals were naturally 
      resistant. Intraperitoneal (ip) was more effective than the subcutaneous (sc) 
      route of inoculation, and the induction of disease-resistance correlated with the 
      production of IgG anti-Leishmania in CBA/ca, C57BL/6 and C57BL/10 mice.
FAU - Lezama-Davila, C M
AU  - Lezama-Davila CM
AD  - Centro de Investigaciones en Enfermedades Tropicales, Universidad Autonoma de 
      Campeche, Mexico.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Antigens, Surface)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Liposomes)
RN  - 0 (Membrane Proteins)
RN  - 0 (Protozoan Proteins)
RN  - 0 (Protozoan Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Protozoan/biosynthesis/immunology
MH  - Antigens, Protozoan/administration & dosage/*immunology
MH  - Antigens, Surface/administration & dosage/*immunology
MH  - Disease Susceptibility
MH  - Immunoglobulin G/biosynthesis
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Leishmania mexicana/*immunology
MH  - Leishmaniasis, Cutaneous/*prevention & control
MH  - Liposomes
MH  - Membrane Proteins/administration & dosage/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Mice, Inbred NZB
MH  - Protozoan Proteins/administration & dosage/*immunology
MH  - Protozoan Vaccines/administration & dosage/*immunology
MH  - *Vaccination/methods
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PST - ppublish
SO  - Arch Med Res. 1997 Spring;28(1):47-53.