PMID- 9079771
OWN - NLM
STAT- MEDLINE
DCOM- 19970613
LR  - 20190826
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 84
IP  - 1-2
DP  - 1997 Mar
TI  - Kainic acid lesions enhance locomotor responses to novelty, saline, amphetamine, 
      and MK-801.
PG  - 47-55
AB  - Intracerebroventricular (i.c.v.) administration of kainic acid (KA) to rats 
      produces neuronal loss in the hippocampus and other areas of the limbic system. 
      The present study demonstrates that i.c.v. KA enhances the locomotor response to 
      novelty and saline injection, as well as to amphetamine and MK-801. Sixteen to 18 
      days after i.c.v. administration of KA or vehicle, lesioned and control rats were 
      placed in a novel cage, and locomotor activity and grooming were recorded for 30 
      min prior to and 60 min following a subcutaneous injection of saline, 
      D-amphetamine, or MK-801. In response to the novel cage and after each injection, 
      KA rats exhibited increased locomotor activity relative to controls. Grooming 
      behavior was found to be elevated in the KA rats when compared to controls, but 
      only in response to the novel cage and saline injection. The possibility that 
      damage to the limbic system disrupts dopaminergic regulation of locomotor 
      behavior is discussed, as well as implications for neuropathology in 
      schizophrenia.
FAU - Bardgett, M E
AU  - Bardgett ME
AD  - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 
      63110-1093, USA. bardgetm@medicine.wustl.edu
FAU - Jacobs, P S
AU  - Jacobs PS
FAU - Jackson, J L
AU  - Jackson JL
FAU - Csernansky, J G
AU  - Csernansky JG
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - SIV03811UC (Kainic Acid)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Dextroamphetamine/pharmacology
MH  - Dizocilpine Maleate/pharmacology
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - *Environment
MH  - Excitatory Amino Acid Agonists/*toxicity
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Grooming/drug effects
MH  - Hippocampus/cytology/drug effects
MH  - Injections, Intraventricular
MH  - Kainic Acid/*toxicity
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0166-4328(96)00132-5 [pii]
AID - 10.1016/s0166-4328(96)00132-5 [doi]
PST - ppublish
SO  - Behav Brain Res. 1997 Mar;84(1-2):47-55. doi: 10.1016/s0166-4328(96)00132-5.