PMID- 9080394
OWN - NLM
STAT- MEDLINE
DCOM- 19970610
LR  - 20190831
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 92
IP  - 2-3
DP  - 1996 Dec 20
TI  - Long-term effects of caloric restriction initiated at different ages on DNA 
      polymerases in rat brain.
PG  - 133-42
AB  - Caloric restriction (CR), has been shown to extend life span and delay both aging 
      and the onset of a number of life-shortening diseases in laboratory animals. 
      Defective DNA repair and DNA damage have been implicated as causal factors in 
      many of these disease processes. CR appears to increase genetic stability by 
      enhancing the DNA repair capacity and reducing the age-related accumulation of 
      certain types of DNA damage. In the present study, we examined the effects of CR, 
      imposed during four discrete periods of the life span of male Wistar rats, on the 
      activity of total DNA polymerases of an aged brain which in turn may have a 
      bearing on the process of aging. Our data indicates that CR had a greater 
      stimulatory response on the activity of total DNA polymerases measured at 28 
      months of age in rats restricted from 6 to 28 months of age than in those 
      restricted from postnatal day (PND) 7-21 which in turn was higher than those 
      restricted from birth to PND 21. CR had differential effects in different regions 
      of the brain. The enzyme activity of total DNA polymerases was significantly 
      increased in hypothalamus and hippocampus. Cerebral cortex and corpus striatum 
      are the regions which show no significant changes by CR regardless of age or 
      duration of treatment while cerebellum registered a decrease during all periods 
      of restriction. Modification of caloric intake alters total DNA polymerase 
      activity and the extent of modification is both age and tissue dependent. Also, 
      it appears that the effects of CR depend on when the paradigm is initiated, and 
      are not solely a linear function of its duration.
FAU - Prapurna, D R
AU  - Prapurna DR
AD  - Department of Biochemistry, School of Life Sciences, University of Hyderabad, 
      India.
FAU - Rao, K S
AU  - Rao KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Biomarkers)
RN  - EC 2.7.7.7 (DNA-Directed DNA Polymerase)
SB  - IM
MH  - Aging/*metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Biomarkers
MH  - Brain/*enzymology
MH  - *DNA Repair
MH  - DNA-Directed DNA Polymerase/*metabolism
MH  - *Energy Intake
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 1996/12/20 00:00
MHDA- 1996/12/20 00:01
CRDT- 1996/12/20 00:00
PHST- 1996/12/20 00:00 [pubmed]
PHST- 1996/12/20 00:01 [medline]
PHST- 1996/12/20 00:00 [entrez]
AID - S0047-6374(96)01815-5 [pii]
AID - 10.1016/s0047-6374(96)01815-5 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 1996 Dec 20;92(2-3):133-42. doi: 10.1016/s0047-6374(96)01815-5.