PMID- 9081637
OWN - NLM
STAT- MEDLINE
DCOM- 19970403
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 8
IP  - 4
DP  - 1996 Apr
TI  - Reserpine affects differentially the density of the vesicular monoamine 
      transporter and dihydrotetrabenazine binding sites.
PG  - 842-6
AB  - We have studied the effect of a single injection of reserpine (5 mg/kg, s.c.) on 
      the synaptic vesicle monoamine transporter (VMAT) density in the rat striatum, 
      using two labelling procedures: radioimmunolabelling with an antibody against 
      VMAT, and binding of the specific ligand [(3)H]dihydrotetrabenazine 
      ([(3)H]TBZOH). In the rostral and medial striatum, the distribution of VMAT 
      immunoreactivity displayed the highest density in the lateral subregions. In the 
      caudal part of the striatum, VMAT immunoreactivity showed increasing density from 
      dorsal to ventral subregions. The VMAT immunoreactivity was not altered 2 and 30 
      days after the reserpine injection, whereas [(3)H]TBZOH binding site density, 
      measured on adjacent slices, showed a dramatic decrease at day 2 and a moderate 
      recovery at day 30, suggesting that despite a persistent blockade of [(3)H]TBZOH 
      binding sites, VMAT protein density was unchanged.
FAU - Naudon, L
AU  - Naudon L
AD  - Unite de Neuropsychopharmacologie Experimentale, CNRS URA 1969, Faculte de 
      Medecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
FAU - Raisman-Vozari, R
AU  - Raisman-Vozari R
FAU - Edwards, R H
AU  - Edwards RH
FAU - Leroux-Nicollet, I
AU  - Leroux-Nicollet I
FAU - Peter, D
AU  - Peter D
FAU - Liu, Y
AU  - Liu Y
FAU - Costentin, J
AU  - Costentin J
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Vesicular Biogenic Amine Transport Proteins)
RN  - 0 (Vesicular Monoamine Transport Proteins)
RN  - 3466-75-9 (dihydrotetrabenazine)
RN  - 8B1QWR724A (Reserpine)
RN  - Z9O08YRN8O (Tetrabenazine)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Binding Sites/drug effects
MH  - Corpus Striatum/drug effects/metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - *Membrane Transport Proteins
MH  - *Neuropeptides
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reserpine/*pharmacology
MH  - Tetrabenazine/*analogs & derivatives/metabolism
MH  - Vesicular Biogenic Amine Transport Proteins
MH  - Vesicular Monoamine Transport Proteins
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1111/j.1460-9568.1996.tb01271.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1996 Apr;8(4):842-6. doi: 10.1111/j.1460-9568.1996.tb01271.x.