PMID- 9082281
OWN - NLM
STAT- MEDLINE
DCOM- 19970401
LR  - 20191210
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 104
IP  - 3
DP  - 1997 Mar
TI  - Role of ABO and Lewis blood group antigens in donor-recipient compatibility of 
      corneal transplantation rejection.
PG  - 508-12
AB  - PURPOSE: There are conflicting results regarding the role of human leukocyte 
      antigen (HLA) matching and ABO compatibility in corneal graft rejection for low- 
      and high-risk patients. Lewis blood group antigens could be an important 
      histocompatibility system. Beneficial effects of Lewis antigens matching have 
      been reported in renal transplantation, but its effect is still unknown in 
      corneal allografting. METHODS: Between 1987 and 1993, ABO, Lewis and HLA 
      phenotypes were determined in 697 consecutive grafts of corneal transplantations. 
      The effect of Lewis matching on corneal endothelial rejection was evaluated over 
      a 3-year period. Data analysis was done by plotting survival curves with the 
      Kaplan-Meier method for survivorship data and performing statistical analysis 
      with the log-rank test (Mantel-Haenszel test) for curve comparison. RESULTS: In 
      vascularized recipients, the ABO, Lewis, and HLA systems did not influence the 
      graft outcome. However, for the unvascularized recipients, the endothelial 3-year 
      rejection rate was significantly lower for both Lewis compatible patients (84% 
      vs. 68%; log rank = 0.03) and HLA compatible patients (86% vs 72%; log rank = 
      0.001), but not for the ABO-matched patients (82% vs. 79%; log rank = 0.56). 
      CONCLUSIONS: The authors' study suggests that Lewis antigens and HLA matching 
      could positively influence corneal graft survival for the unvascularized 
      recipients, but it did not seem to have any effect in vascularized recipients.
FAU - Roy, R
AU  - Roy R
AD  - Rheumatology-Immunology Research Center, Centre Hospitalier Universitaire de 
      Quebec, Ste-Foy, Canada.
FAU - Des Marchais, B
AU  - Des Marchais B
FAU - Bazin, R
AU  - Bazin R
FAU - Boisjoly, H M
AU  - Boisjoly HM
FAU - Dube, I
AU  - Dube I
FAU - Laughrea, P A
AU  - Laughrea PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
RN  - 0 (Lewis Blood Group Antigens)
SB  - IM
MH  - ABO Blood-Group System/*physiology
MH  - Corneal Transplantation/*immunology
MH  - Graft Rejection/*immunology
MH  - Graft Survival/physiology
MH  - HLA Antigens/*physiology
MH  - *Histocompatibility
MH  - Humans
MH  - Lewis Blood Group Antigens/*physiology
MH  - Prospective Studies
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0161-6420(97)30283-8 [pii]
AID - 10.1016/s0161-6420(97)30283-8 [doi]
PST - ppublish
SO  - Ophthalmology. 1997 Mar;104(3):508-12. doi: 10.1016/s0161-6420(97)30283-8.