PMID- 9082830
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20090723
IS  - 0392-100X (Print)
IS  - 0392-100X (Linking)
VI  - 16
IP  - 4
DP  - 1996 Aug
TI  - [Laryngeal cancer and angiogenesis].
PG  - 355-62
AB  - Angiogenesis is required for the growth of solid tumors which, in avascular 
      condition, are limited to 2-3 mm3 volume. The switch to the angiogenic phenotype 
      allows new vessels to converge upon the tumor, growth to proceed at an 
      exponential rate and metastasis diffusion. The evaluation of tumoral angiogenesis 
      has been proposed to be an independent prognostic marker of behaviour of some 
      solid tumors: it has been demonstrated that, in some types of carcinoma (breast, 
      prostate, lung, etc...), an intense vascular proliferation correlates with the 
      aggressiveness of the disease. However in malignant melanomas and colorectal 
      carcinomas, there are conflicting results on the correlation between angiogenesis 
      and the progression of the cancer. There are also conflicting data on the role of 
      microvessels count (MC) in the management of head and neck cancer. Despite a 
      large number of studies, at the present, there are not biological or molecular 
      markers available to predict consistently the outcome of the patients with 
      laryngeal squamous cell carcinoma (LSCC). In fact the prognosis of this tumor has 
      been mainly based, up to now, on a number of clinico-pathological parameters, 
      especially localization, tumor extent and nodal involvement. The aim of this 
      study has been to compare MC inside LSCC with disease free survival, grading, pT, 
      pN and pathological stage. We investigated the relevance of the number of 
      microvessels in the peritumoral stroma of 68 LSCC (only Caucasian males, age 
      35-70 years), classified according to UICC/1987 randomly selected (33 classified 
      in clinical stage I e II and 35 in clinical stage III-IV). All patients have been 
      surgically treated and pN + cases have been also submitted to radiotherapy. The 
      follow-up was 60-84 months. The vascular density was assessed according to Horak 
      et Al. with an immunohistochemical method using JC70 monoclonal antibody (CD31; 
      Dako, Astrup, Denmark). Univariate analysis showed that MC, pT, pN, Pathological 
      Stage and grading were correlated with the disease-free survival. A MC < 120/mm2 
      was predictive for a high survival index; in contrast a MC > 150 mm2 were 
      associated with relapse. Furthermore, multivariate analysis demonstrated that MC 
      was the only independent predictor for the disease free survival. Our findings 
      demonstrate that in LSCC, MC is the first measurable biological parameter which 
      is significant for evaluating the disease free-survival. Therefore, MC in LSCC is 
      crucial in the prognosis and in the choice of a more aggressive management of the 
      disease, including the possible treatment with antiangiogenic compound.
FAU - Beatrice, F
AU  - Beatrice F
AD  - Dipartimento di Fisiopatologia Clinica, Universita di Torino.
FAU - Valente, G
AU  - Valente G
FAU - Cammarota, R
AU  - Cammarota R
FAU - Bisciari, T
AU  - Bisciari T
FAU - Ragona, R
AU  - Ragona R
FAU - Giusti, U
AU  - Giusti U
FAU - Bussolino, F
AU  - Bussolino F
FAU - Sartoris, A
AU  - Sartoris A
LA  - ita
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Angiogenesi e cancro della laringe.
PL  - Italy
TA  - Acta Otorhinolaryngol Ital
JT  - Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di 
      otorinolaringologia e chirurgia cervico-facciale
JID - 8213019
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/mortality/*pathology/ultrastructure
MH  - Humans
MH  - Laryngeal Neoplasms/mortality/*pathology/ultrastructure
MH  - Larynx/*pathology/ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Acta Otorhinolaryngol Ital. 1996 Aug;16(4):355-62.