PMID- 9084876
OWN - NLM
STAT- MEDLINE
DCOM- 19970619
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 20
IP  - 3
DP  - 1997 Mar
TI  - Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet 
      on antigen-induced antibody and anaphylactic responses in mice.
PG  - 217-23
AB  - Previously, we reported that a high alpha-linolenate [18:3(n-3)] diet compared 
      with a high linoleate [18:2(n-6)] diet suppressed the anti-egg albumin (EA) 
      immunoglobulin E (IgE) antibody response in mice. Because of relatively high 
      background values obtained with the method used previously, we used an improved 
      ELISA and once again determined serum IgE levels. In contrast to our previous 
      results, the serum level of anti-dinitrophenyl specific (anti-DNP) as well as 
      total IgE in mice immunized with DNP-antigen was slightly but significantly 
      higher in the high alpha-linolenate diet group than in the high linoleate diet 
      group. Anti-DNP IgG1 and IgG2a antibody responses were not significantly 
      different in mice fed these diets. Indomethacin administration during 
      immunization tended to enhance the IgE antibody responses. The mortality of mice 
      from antigen-induced anaphylactic shock was significantly lower in the high 
      alpha-linolenate diet group than in the high linoleate diet group; however, there 
      was no difference between the groups in terms of vascular permeability and 
      histamine levels. Thus, the high alpha-linolenate diet enhances the IgE antibody 
      response slightly without affecting either the IgG antibody response, vascular 
      permeability or histamine release. The high alpha-linolenate diet possibly 
      suppresses anaphylactic shock by reducing the synthesis of lipid mediators such 
      as eicosanoids and platelet-activating factor.
FAU - Oh-hashi, K
AU  - Oh-hashi K
AD  - Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya 
      City University, Japan.
FAU - Watanabe, S
AU  - Watanabe S
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Okuyama, H
AU  - Okuyama H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Dinitrophenols)
RN  - 0 (Fatty Acids)
RN  - 0 (Linoleic Acids)
RN  - 0 (Lipids)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Anaphylaxis/mortality/*physiopathology
MH  - Animals
MH  - Antibody Formation/*drug effects
MH  - Capillary Permeability/drug effects/physiology
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - *Diet
MH  - Dinitrophenols/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fatty Acids/blood
MH  - Female
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/analysis
MH  - Indomethacin/pharmacology
MH  - Linoleic Acids/*pharmacology
MH  - Lipids/blood
MH  - Mice
MH  - Mice, Inbred C3H
MH  - alpha-Linolenic Acid/*pharmacology
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1248/bpb.20.217 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 1997 Mar;20(3):217-23. doi: 10.1248/bpb.20.217.