PMID- 9086442
OWN - NLM
STAT- MEDLINE
DCOM- 19970708
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 24
IP  - 5-6
DP  - 1997 Feb
TI  - Clonal identification of trisomies 3, 5 and X in angioimmunoblastic 
      lymphadenopathy with dysproteinemia by fluorescence in situ hybridization.
PG  - 523-32
AB  - Trisomies 3, 5 and X in six Japanese patients with AILD were detected by 
      fluorescence in situ hybridization (FISH). Trisomies 3 and X were detected using 
      centromeric probes. Cosmid probes locating on 5q31.1, the commonly deleted 
      region, was used to detect trisomy 5. FISH detected three patients with trisomy 3 
      alone, one with trisomy 5 alone and one with all the three trisomies analysed. 
      The sample that showed all three aberrations was further analysed by dual color 
      FISH. The three trisomies were present on different cells. The AILD cells with 
      trisomy 5 tended to replicate slowly, whereas those with trisomy 3 seem to have a 
      proliferative advantage. An increase in the histopathological stage was reflected 
      in the increase in the percentage of trisomy 3 cells in one patient.
FAU - Kumaravel, T S
AU  - Kumaravel TS
AD  - Department of Cancer Cytogenetics, Hiroshima University, Japan.
FAU - Tanaka, K
AU  - Tanaka K
FAU - Arif, M
AU  - Arif M
FAU - Ohshima, K
AU  - Ohshima K
FAU - Ohgami, A
AU  - Ohgami A
FAU - Takeshita, M
AU  - Takeshita M
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Kamada, N
AU  - Kamada N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Protein Disorders/blood/*genetics
MH  - *Chromosomes, Human, Pair 3
MH  - *Chromosomes, Human, Pair 5
MH  - Female
MH  - Humans
MH  - Immunoblastic Lymphadenopathy/blood/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
MH  - *X Chromosome
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.3109/10428199709055589 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1997 Feb;24(5-6):523-32. doi: 10.3109/10428199709055589.