PMID- 908685
OWN - NLM
STAT- MEDLINE
DCOM- 19771130
LR  - 20171213
IS  - 0161-7567 (Print)
IS  - 0161-7567 (Linking)
VI  - 43
IP  - 4
DP  - 1977 Oct
TI  - Effects of elevated plasma FFA and insulin on muscle glycogen usage during 
      exercise.
PG  - 695-9
AB  - Seven men were studied during 30 min of treadmill exercise (approximately 70% VO2 
      max) to determine the effects of increased availability of plasma free fatty 
      acids (FFA) and elevated plasma insulin on the utilization of muscle glycogen. 
      This elevation of plasma FFA (1.01 mmol/1) with heparin (2,000 units) decreased 
      the rate of muscle glycogen depletion by 40% as compared to the control 
      experiment (FFA = 0.21 mmol/1). The ingestion of 75 g of glucose 45 min before 
      exercise produced a 3.3-fold increase in plasma insulin and a 38% rise in plasma 
      glucose at 0 min of exercise. Subsequent exercise increased muscle glycogen 
      utilization and total carbohydrate (CHO) oxidation 17 and 13%, respectively, when 
      compared to the control trial. This elevation of plasma insulin produced 
      hypoglycemia (less than 3.5 mmol/1) in most subjects throughout the exercise. 
      These data illustrate the regulatory influence of both plasma insulin and FFA on 
      the rate of CHO usage during prolonged severe muscular activity.
FAU - Costill, D L
AU  - Costill DL
FAU - Coyle, E
AU  - Coyle E
FAU - Dalsky, G
AU  - Dalsky G
FAU - Evans, W
AU  - Evans W
FAU - Fink, W
AU  - Fink W
FAU - Hoopes, D
AU  - Hoopes D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Appl Physiol Respir Environ Exerc Physiol
JT  - Journal of applied physiology: respiratory, environmental and exercise physiology
JID - 7801242
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - 0 (Triglycerides)
RN  - 9005-79-2 (Glycogen)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Fatty Acids, Nonesterified/*blood
MH  - Glycerol/blood
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Insulin/*blood
MH  - Lactates/blood
MH  - Lipid Metabolism
MH  - Male
MH  - Muscles/*metabolism
MH  - Oxygen Consumption
MH  - *Physical Exertion
MH  - Physical Fitness
MH  - Triglycerides/blood
EDAT- 1977/10/01 00:00
MHDA- 1977/10/01 00:01
CRDT- 1977/10/01 00:00
PHST- 1977/10/01 00:00 [pubmed]
PHST- 1977/10/01 00:01 [medline]
PHST- 1977/10/01 00:00 [entrez]
AID - 10.1152/jappl.1977.43.4.695 [doi]
PST - ppublish
SO  - J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):695-9. doi: 
      10.1152/jappl.1977.43.4.695.