PMID- 9087572
OWN - NLM
STAT- MEDLINE
DCOM- 19970702
LR  - 20191024
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 18
IP  - 4
DP  - 1997 Apr
TI  - Frequent deletions of 6q23-24 in B-cell non-Hodgkin's lymphomas detected by 
      fluorescence in situ hybridization.
PG  - 310-3
AB  - Deletions of the long arm of chromosome 6 (6q) are among the most frequent 
      chromosome aberrations in malignant lymphomas and often occur as secondary 
      changes in addition to typical translocations, such as t(14;18). Using 
      fluorescence in situ hybridization (FISH) with two YAC probes hybridizing to 
      6q23-24 and with the centromeric probe D6Z1 as internal control, we studied 31 
      cases of low-grade and eight cases of high-grade B-cell lymphoma. Deletions of 
      6q23-24 were detected in 21 patients (56.8%) by FISH, compared to 13 patients 
      (33.3%) by chromosome analysis. Deletions of 6q23-24 were found by FISH in 5 of 
      13 cases of small lymphocytic lymphoma, in 2 of 3 cases of mantle cell lymphoma, 
      in 10 of 14 cases of t(14;18) positive low-grade follicular lymphoma, and in 4 of 
      8 cases of high-grade follicular lymphoma. This study shows that deletions of 
      6q23-24 are more frequent in B-cell lymphomas than previously suggested and that 
      they can be detected more sensitively by FISH than by chromosome analysis. 
      Contrary to previous reports indicating that the region 6q23-24 is preferentially 
      deleted in low-grade lymphomas without t(14;18), our results indicate that 
      deletions of 6q23-24 appear to be common in other pathological subsets of B-cell 
      lymphoma as well, especially in follicular lymphomas with t(14;18).
FAU - Zhang, Y
AU  - Zhang Y
AD  - Department of Human Genetics, University of Kiel, Germany.
FAU - Weber-Matthiesen, K
AU  - Weber-Matthiesen K
FAU - Siebert, R
AU  - Siebert R
FAU - Matthiesen, P
AU  - Matthiesen P
FAU - Schlegelberger, B
AU  - Schlegelberger B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA Probes)
SB  - IM
MH  - Centromere
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/*genetics
MH  - Polyploidy
EDAT- 1997/04/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199704)18:4<310::AID-GCC10>3.0.CO;2-K [pii]
AID - 10.1002/(sici)1098-2264(199704)18:4<310::aid-gcc10>3.0.co;2-k [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1997 Apr;18(4):310-3. doi: 
      10.1002/(sici)1098-2264(199704)18:4<310::aid-gcc10>3.0.co;2-k.