PMID- 9088067
OWN - NLM
STAT- MEDLINE
DCOM- 19970527
LR  - 20191101
IS  - 8756-0437 (Print)
IS  - 1098-2388 (Linking)
VI  - 13
IP  - 2
DP  - 1997 Mar-Apr
TI  - Parathyroid glands and the multiple endocrine neoplasia syndromes and familial 
      hypocalciuric hypercalcemia.
PG  - 114-24
AB  - Hypercalcemia is a variable feature of inherited endocrine disorders. In the 
      multiple endocrine neoplasia (MEN) syndromes, generalized hyperparathyroidism is 
      a common feature. It occurs much more frequently in patients with MEN type 1 as 
      compared to patients with MEN type 2A. Unlike the MEN syndromes, patients with 
      familial hypocalciuric hypercalcemia (FHH) have only hypercalcemia with no 
      associated endocrinopathies. The hyperparathyroidism in patients with either of 
      the MEN syndromes is managed by parathyroidectomy, whereas patients with FHH are 
      managed nonoperatively. The specific genetic defects associated with MEN type 2 
      syndromes and FHH have been identified. They explain, in part, the clinical and 
      pathophysiologic features of these diseases. The genetic defect causative of MEN 
      type 1 will doubtless soon be found and thereby provide further insights into the 
      molecular basis of calcium homeostasis. We will review the clinical presentation 
      and the management of patients with these disorders. We will also review the 
      recent molecular discoveries in MEN 2A, MEN 2B, and FHH, and define how they have 
      altered the management of patients who have these syndromes.
FAU - Herfarth, K K
AU  - Herfarth KK
AD  - Department of Surgery, Washington University School of Medicine, St. Louis, 
      Missouri 63110, USA.
FAU - Wells, S A Jr
AU  - Wells SA Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Surg Oncol
JT  - Seminars in surgical oncology
JID - 8503713
SB  - IM
MH  - Humans
MH  - *Hypercalcemia/genetics/physiopathology/therapy
MH  - *Hyperparathyroidism/etiology/therapy
MH  - *Multiple Endocrine Neoplasia/genetics/physiopathology/therapy
MH  - Parathyroid Glands/pathology/physiopathology
MH  - Parathyroidectomy
RF  - 57
EDAT- 1997/03/01 00:00
MHDA- 2000/06/22 10:00
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2388(199703/04)13:2<114::AID-SSU7>3.0.CO;2-C [pii]
AID - 10.1002/(sici)1098-2388(199703/04)13:2<114::aid-ssu7>3.0.co;2-c [doi]
PST - ppublish
SO  - Semin Surg Oncol. 1997 Mar-Apr;13(2):114-24. doi: 
      10.1002/(sici)1098-2388(199703/04)13:2<114::aid-ssu7>3.0.co;2-c.