PMID- 9089819
OWN - NLM
STAT- MEDLINE
DCOM- 19970627
LR  - 20190826
IS  - 0033-2917 (Print)
IS  - 0033-2917 (Linking)
VI  - 27
IP  - 2
DP  - 1997 Mar
TI  - Long-term morbidity associated with delayed treatment of first admission 
      schizophrenic patients: a re-analysis of the Camarillo State Hospital data.
PG  - 261-8
AB  - BACKGROUND: The authors examined data from a follow-up study of first admission 
      schizophrenic patients treated with and without antipsychotic medications, who 
      were discharged from the hospital within 6 months. It was predicted that patients 
      who did not require antipsychotic medications for discharge would have a more 
      favourable long-term outcome. METHODS: The subjects were part of the Camarillo 
      State Hospital study conducted by May and colleagues in the late 1950s and early 
      1960s. Patients had been randomly assigned to treatment with and without 
      antipsychotic medications. The number of rehospitalization days and total 
      prescribed chlorpromazine equivalents were calculated for each patient for the 2 
      years following discharge. In order to assess patients' continuing ability to 
      function, 11 patients from each group who met DSM-IV criteria for schizophrenia 
      were matched for age, educational status at first admission, race, and gender; 
      their Global Assessment of Functioning Scale (GAF) score was estimated across a 
      period of 6-7 years following discharge. RESULTS: During the second year 
      following discharge, patients initially treated with antipsychotic medications 
      required fewer rehospitalization days than the initially non-medicated patients. 
      Furthermore, 6-7 years following initial discharge, those patients initially 
      treated with medications were functioning at a higher level, as measured by GAF 
      scores, than patients not initially treated with antipsychotic medications. 
      CONCLUSIONS: The results of this study suggest that, at least for this subgroup 
      of patients, early treatment with antipsychotic medications both decreases the 
      immediate morbidity associated with schizophrenia, and prevents detrimental 
      changes possibly related to prolonged untreated psychosis.
FAU - Wyatt, R J
AU  - Wyatt RJ
AD  - Neuropsychiatry Branch, IRP, National Institute of Mental Health, NIMH 
      Neuropsychiatric Hospital, Washington, DC 20032, USA.
FAU - Green, M F
AU  - Green MF
FAU - Tuma, A H
AU  - Tuma AH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Antipsychotic Agents)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/adverse effects/*therapeutic use
MH  - California/epidemiology
MH  - Chlorpromazine/adverse effects/therapeutic use
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitals, State
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Discharge/statistics & numerical data
MH  - Patient Readmission/*statistics & numerical data
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/diagnosis/*drug therapy/epidemiology
MH  - *Schizophrenic Psychology
MH  - Treatment Outcome
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1017/s0033291796004345 [doi]
PST - ppublish
SO  - Psychol Med. 1997 Mar;27(2):261-8. doi: 10.1017/s0033291796004345.