PMID- 9090200
OWN - NLM
STAT- MEDLINE
DCOM- 19970519
LR  - 20190512
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 37
IP  - 4
DP  - 1996 Dec
TI  - Chromosomal aberrations detected by chromosome painting in lymphocytes from 
      cancer patients given high doses of therapeutic X-rays.
PG  - 257-65
AB  - Chromosome painting by fluorescence in situ hybridization (FISH) with a whole 
      chromosome-specific DNA probe was used to detect chromosomal aberrations in 
      lymphocytes from cancer patients given partial-body fractionated X-ray therapy. 
      Six male patients with cancer of the stomach, prostate, lung, or hepatocellular 
      carcinoma, received X-rays in total doses of 40.5 to 70.08 Gy. Lymphocytes were 
      cultured for 50 h with phytohemagglutinin. The mean frequency of aberrant cells 
      detected by chromosome 4 painting varied from 1.57% to 14.34% in the patients and 
      was markedly higher than in healthy controls (mean = 0.12%). Chromosome painting 
      effectively detected chromosomal aberrations in lymphocytes from cancer patients. 
      Equivalent biological doses extrapolated from a dose-response curve obtained in 
      an in vitro human lymphocyte X-ray irradiation study are discussed as an 
      indicator of the cytogenetic damage inducible by radiotherapy in cancer patients.
FAU - Matsuoka, A
AU  - Matsuoka A
AD  - Division of Genetics and Mutagenesis, National Institute of Health Sciences, 
      Tokyo, Japan. matsuoka@nihs.go.jp
FAU - Yamada, K
AU  - Yamada K
FAU - Hayashi, M
AU  - Hayashi M
FAU - Sofuni, T
AU  - Sofuni T
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Humans
MH  - Lymphocytes/*radiation effects/ultrastructure
MH  - Male
MH  - Neoplasms/*genetics/*radiotherapy
MH  - Radiotherapy Dosage
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1269/jrr.37.257 [doi]
PST - ppublish
SO  - J Radiat Res. 1996 Dec;37(4):257-65. doi: 10.1269/jrr.37.257.