PMID- 909048
OWN - NLM
STAT- MEDLINE
DCOM- 19771130
LR  - 20181130
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 203
IP  - 1
DP  - 1977 Oct
TI  - Central and peripheral adrenergic mechanisms regulating gastric secretion in the 
      rat.
PG  - 125-31
AB  - Subcutaneous injection of sympathomimetic agents reduced gastric secretion in 
      pylorus-ligated rats, and the decreasing order of activity was: isoproterenol, 
      norepinephrine, naphazoline and phenylephrine. The effect of naphazoline and 
      phenylephrine was antagonized with 4 mg/kg s.c. of phentolamine, and that of 
      isoproterenol with 4 mg/kg s.c. of propranolol. Thus there exist separate, alpha 
      and beta adrenergic receptors which control gastric secretion in the rat. 
      Intracerebroventricular (i.c.v.) injection of the sympathomimetic agents also 
      reduced secretion, naphazoline being the most potent. The ED50 of i.c.v. 
      naphazoline was 12.3 times less than that of s.c. dose. The antisecretory effect 
      of i.c.v. naphazoline was antagonized with i.c.v. phentolamine (0.016 and 0.064 
      mg/kg), but not with propranolol. These results suggest that naphazoline 
      stimulates central alpha adrenergic receptors which has a tonic inhibiting role 
      in rat gastric secretion. Analogous to the results with naphazoline, i.c.v. 
      phentolamine, but not propranolol, blocked an antisecretory effect of 
      chlorpromazine. Phentolamine administered s.c. also reduced the antisecretory 
      activity, but the dose required for the antagonism was 250 times that of i.c.v. 
      phentolamine. An antisecretory effect of imipramine was not blocked by 
      phentolamine or propranolol. These results suggest that an activation of central 
      alpha adrenergic receptors is important for the antisecretory effect of 
      chlorpromazine.
FAU - Yamaguchi, I
AU  - Yamaguchi I
FAU - Hiroi, J
AU  - Hiroi J
FAU - Kumada, S
AU  - Kumada S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Sympatholytics)
RN  - 0 (Sympathomimetics)
RN  - OGG85SX4E4 (Imipramine)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Animals
MH  - Chlorpromazine/pharmacology
MH  - Gastric Mucosa/drug effects/*metabolism
MH  - Imipramine/pharmacology
MH  - Injections, Intraventricular
MH  - Ligation
MH  - Male
MH  - Pyloric Antrum/physiology
MH  - Rats
MH  - Sympathetic Nervous System/*physiology
MH  - Sympatholytics/pharmacology
MH  - Sympathomimetics/pharmacology
EDAT- 1977/10/01 00:00
MHDA- 1977/10/01 00:01
CRDT- 1977/10/01 00:00
PHST- 1977/10/01 00:00 [pubmed]
PHST- 1977/10/01 00:01 [medline]
PHST- 1977/10/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1977 Oct;203(1):125-31.