PMID- 9092522
OWN - NLM
STAT- MEDLINE
DCOM- 19970515
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 272
IP  - 15
DP  - 1997 Apr 11
TI  - Plasticity of tetramer formation by retinoid X receptors. An alternative paradigm 
      for DNA recognition.
PG  - 9860-7
AB  - Retinoid X receptors (RXRs) are transcription factors that traditionally have 
      been thought to bind DNA as protein dimers. Recently, however, it has been 
      recognized that RXRs can also bind to DNA as protein tetramers. Receptor 
      tetramers form cooperatively on response elements containing suitably reiterated 
      half-sites, and play an important role in determining the specificity of DNA 
      recognition by different nuclear receptors. We report here that RXR tetramers 
      exhibit significant functional plasticity, and form on response elements 
      possessing diverse half-site orientations and spacings. This ability of RXRs to 
      form tetramers and related oligomers appears to contribute to the synergistic 
      transcriptional activation observed when multiple, spatially separated response 
      elements are introduced into a single promoter. Oligomerization may therefore be 
      a common paradigm for DNA recognition and combinatorial regulation by several 
      different classes of transcription factors.
FAU - Lin, B C
AU  - Lin BC
AD  - Section of Microbiology, Division of Biological Sciences, University of 
      California, Davis, California 95616, USA.
FAU - Wong, C W
AU  - Wong CW
FAU - Chen, H W
AU  - Chen HW
FAU - Privalsky, M L
AU  - Privalsky ML
LA  - eng
GR  - GM 08343-07/GM/NIGMS NIH HHS/United States
GR  - R37 CA-53394/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA-Binding Proteins/chemistry/*metabolism
MH  - Genes, Reporter
MH  - Mice
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/chemistry/*metabolism
MH  - Protein Conformation
MH  - Receptors, Retinoic Acid/chemistry/*metabolism
MH  - Retinoid X Receptors
MH  - Transcription Factors/chemistry/*metabolism
EDAT- 1997/04/11 00:00
MHDA- 1997/04/11 00:01
CRDT- 1997/04/11 00:00
PHST- 1997/04/11 00:00 [pubmed]
PHST- 1997/04/11 00:01 [medline]
PHST- 1997/04/11 00:00 [entrez]
AID - S0021-9258(18)40826-5 [pii]
AID - 10.1074/jbc.272.15.9860 [doi]
PST - ppublish
SO  - J Biol Chem. 1997 Apr 11;272(15):9860-7. doi: 10.1074/jbc.272.15.9860.