PMID- 9093820
OWN - NLM
STAT- MEDLINE
DCOM- 19970605
LR  - 20131121
IS  - 0378-6501 (Print)
IS  - 0378-6501 (Linking)
VI  - 23
IP  - 1
DP  - 1997
TI  - Effects of nedocromil sodium on the oxidative burst of polymorphonuclear 
      leukocytes: comparison with salbutamol.
PG  - 33-8
AB  - The effects of nedocromil sodium and of salbutamol on the generation of 
      oxygen-derived free radicals in human polymorphonuclear leukocytes (PMNs) were 
      compared in vitro by the luminol-amplified-chemiluminescence (LACL) assay induced 
      by both particulate (Candida albicans) and soluble 
      formyl-methionyl-leucyl-phenylalanine (fMLP) stimulants. Inhibitory dose-effect 
      linear regressions were observed from 10(-3) to 10(-8) M for nedocromil and 
      salbutamol after a 3' period of incubation with either C. albicans or fMLP. There 
      was a linear regression with nedocromil sodium after 30' incubation, but 
      desensitization was observed with salbutamol after this longer period of 
      incubation. The generation of oxygen-derived free radicals was significantly 
      greater for asthmatic patients than for normal subjects; therefore antiasthmatic 
      drugs with this inhibitory activity could be an extra pharmacological benefit in 
      the treatment of asthmatic patients.
FAU - Braga, P C
AU  - Braga PC
AD  - Department of Pharmacology, University of Milan, Italy.
FAU - Mancini, L
AU  - Mancini L
FAU - Guffanti, E E
AU  - Guffanti EE
FAU - Dal Sasso, M
AU  - Dal Sasso M
FAU - Sala, M
AU  - Sala M
FAU - Reggio, S
AU  - Reggio S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Drugs Exp Clin Res
JT  - Drugs under experimental and clinical research
JID - 7802135
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Reactive Oxygen Species)
RN  - 0B535E0BN0 (Nedocromil)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Albuterol/*pharmacology
MH  - Analysis of Variance
MH  - Anti-Asthmatic Agents/*pharmacology
MH  - Bronchodilator Agents/*pharmacology
MH  - Candida albicans/drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Linear Models
MH  - Luminescent Measurements
MH  - N-Formylmethionine Leucyl-Phenylalanine/metabolism
MH  - Nedocromil/*pharmacology
MH  - Neutrophils/cytology/*drug effects/metabolism
MH  - Reactive Oxygen Species
MH  - Respiratory Burst/*drug effects
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Drugs Exp Clin Res. 1997;23(1):33-8.