PMID- 9094433
OWN - NLM
STAT- MEDLINE
DCOM- 19970501
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 405
IP  - 1
DP  - 1997 Mar 17
TI  - Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF 
      transcription factor in human hepatoma cells and hepatocytes.
PG  - 99-103
AB  - Acute phase protein expression is regulated by a variety of cytokines such as 
      IL-1, IL-6, IL-11, tumour necrosis factor alpha, interferon-gamma, oncostatin-M, 
      leukemia inhibitory factor, ciliary neurotrophic factor and cardiotrophin-1. 
      Presently, IL-6 is regarded as the most potent mediator of acute phase protein 
      (APP) synthesis. It was shown that IL-6 and IL-6-type cytokines activate the 
      so-called JAK/STAT pathway and finally regulate APP expression in liver cells. 
      Since HGF/SF is also capable of regulating APP expression, we asked whether it 
      might also signal via the JAK/STAT pathway. Here we show that incubation of human 
      hepatocytes as well as hepatoma cells (HepG2) with HGF/SF results in activation 
      of the transcription factor STAT3. This STAT3 activation after HGF/SF did not 
      occur before 5-7 h and was maintained up to 28 h. These observations are in 
      contrast to the rapid and transient activation of STAT1 and STAT3 mediated by 
      IL-6.
FAU - Schaper, F
AU  - Schaper F
AD  - Institut fur Biochemie der RWTH Aachen, Germany.
FAU - Siewert, E
AU  - Siewert E
FAU - Gomez-Lechon, M J
AU  - Gomez-Lechon MJ
FAU - Gatsios, P
AU  - Gatsios P
FAU - Sachs, M
AU  - Sachs M
FAU - Birchmeier, W
AU  - Birchmeier W
FAU - Heinrich, P C
AU  - Heinrich PC
FAU - Castell, J
AU  - Castell J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (alpha 1-Antichymotrypsin)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Carcinoma, Hepatocellular
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Hepatocyte Growth Factor/genetics/*metabolism
MH  - Humans
MH  - Liver/cytology/drug effects/*metabolism
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - STAT3 Transcription Factor
MH  - *Signal Transduction
MH  - Trans-Activators/genetics/*metabolism
MH  - Transcription Factors/genetics/*metabolism
MH  - Tumor Cells, Cultured
MH  - alpha 1-Antichymotrypsin/biosynthesis
EDAT- 1997/03/17 00:00
MHDA- 1997/03/17 00:01
CRDT- 1997/03/17 00:00
PHST- 1997/03/17 00:00 [pubmed]
PHST- 1997/03/17 00:01 [medline]
PHST- 1997/03/17 00:00 [entrez]
AID - S0014579397001671 [pii]
AID - 10.1016/s0014-5793(97)00167-1 [doi]
PST - ppublish
SO  - FEBS Lett. 1997 Mar 17;405(1):99-103. doi: 10.1016/s0014-5793(97)00167-1.