PMID- 9097034
OWN - NLM
STAT- MEDLINE
DCOM- 19970613
LR  - 20231213
IS  - 0378-5866 (Print)
IS  - 0378-5866 (Linking)
VI  - 19
IP  - 2
DP  - 1997
TI  - Connexin32 gene expression in rat sciatic nerves and cultured Schwann cells.
PG  - 189-95
AB  - A Western blot analysis showed connexin32 (Cx32) to be present in the myelin 
      membrane. Cx32 mRNA rapidly decreased in the distal segments of crushed sciatic 
      nerves and thereafter returned to normal, as did P0 mRNA. Both Cx32 and P0 mRNAs 
      were detectable in cultured Schwann cells and were enhanced by the addition of 
      forskolin. The developmental profile showed that Cx32 mRNA had thus markedly 
      increased by the time that myelination had become most active, and thereafter 
      only slowly increased unlike P0. Cx32 mRNA seems to parallel myelin size, which 
      thus suggests that Cx32 supports myelin maintenance as a gap junction protein 
      that facilitates the intramyelin exchange of small molecules.
FAU - Satake, M
AU  - Satake M
AD  - Department of Neurology, Kyushu University, Fukuoka, Japan.
FAU - Yoshimura, T
AU  - Yoshimura T
FAU - Ohnishi, A
AU  - Ohnishi A
FAU - Kobayashi, T
AU  - Kobayashi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
RN  - 0 (Connexins)
RN  - 0 (DNA Probes)
RN  - 0 (RNA, Messenger)
RN  - 1F7A44V6OU (Colforsin)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Cells, Cultured
MH  - Colforsin/pharmacology
MH  - Connexins/*biosynthesis/genetics
MH  - DNA Probes
MH  - Ganglia, Spinal/cytology
MH  - Gene Expression/physiology
MH  - Immunohistochemistry
MH  - Myelin Sheath/metabolism
MH  - Nerve Crush
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schwann Cells/*metabolism
MH  - Sciatic Nerve/*metabolism
MH  - Gap Junction beta-1 Protein
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000111205 [doi]
PST - ppublish
SO  - Dev Neurosci. 1997;19(2):189-95. doi: 10.1159/000111205.