PMID- 9098592
OWN - NLM
STAT- MEDLINE
DCOM- 19970624
LR  - 20200225
IS  - 0160-9289 (Print)
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 20
IP  - 4
DP  - 1997 Apr
TI  - Factors influencing heart rate variability in patients with severe aortic valve 
      disease.
PG  - 341-4
AB  - BACKGROUND AND HYPOTHESIS: Heart rate variability (HRV) is an accepted tool for 
      the assessment of cardiovascular autonomic tone. There are no sufficient data 
      concerning its application to patients with severe aortic valve disease (AVD) 
      requiring cardiac surgery. METHODS: It was the aim of this study to examine HRV 
      and its physiologic correlates in patients with severe aortic valve disease 
      requiring cardiac surgery. The correlates of time domain indices of HRV obtained 
      from 24-h Holter electrocardiographic recordings were analyzed in 36 consecutive 
      patients (23 men and 13 women, mean age 62 +/- 11 years) with AVD prior to 
      cardiac surgery (aortic stenosis: 17 patients, aortic valve regurgitation: 3 
      patients, combined aortic valve disease: 16 patients). RESULTS: Low values of HRV 
      were found in the entire study group: SDNN 96.8 +/- 30.9 ms, SDNNI 39.3 +/- 14.4 
      ms, SDANN 86 +/- 28.9 ms, and RMSSD 30 +/- 18.1 ms. In a univariate analysis, 
      there was no significant correlation between the time domain measures of HRV and 
      age, gender, medication, left ventricular ejection fraction, peak aortic pressure 
      gradient, fraction of aortic valve regurgitation, and left ventricular mass 
      assessed by echocardiography. Patients in advanced functional classes of heart 
      failure [New York Heart Association (NYHA) III or IV] had significantly lower 
      values for SDNN (83.8 +/- 33.6 vs. 107.3 +/- 24.7 ms; p < 0.05) and SDANN (72.7 
      +/- 29.4 vs. 96.6 +/- 24.3 ms; p < 0.05) than patients in NYHA class I or II. 
      Reassessment of HRV 1 week after aortic valve replacement was performed in 17 
      patients and showed a significant further decrease of SDNN (102.4 +/- 29.7 vs. 
      61.5 +/- 23.5 ms; p < 0.001), SDNNI (40.7 +/- 13.6 vs. 23.4 +/- 12.4 ms; p < 
      0.001) and SDANN (91.8 +/- 29.2 vs. 54.2 +/- 22.8 ms; p < 0.001). CONCLUSION: 
      Patients with AVD requiring cardiac surgery reveal reduced time domain indices of 
      HRV. This observation is pronounced in patients with a progressed clinical class 
      of heart failure, whereas hemodynamic and echocardiographic parameters seem to 
      have no significant influence on HRV parameters in this population. In addition, 
      there is evidence of a further reduction of HRV time domain indices 1 week after 
      uncomplicated aortic valve replacement.
FAU - Jung, J
AU  - Jung J
AD  - Medizinische Universitatsklinik, Universitatskliniken des Saarlandes, 
      Homburg/Saar, Germany.
FAU - Heisel, A
AU  - Heisel A
FAU - Tscholl, D
AU  - Tscholl D
FAU - Butz, B
AU  - Butz B
FAU - Fries, R
AU  - Fries R
FAU - Schafers, H J
AU  - Schafers HJ
FAU - Schieffer, H
AU  - Schieffer H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Aortic Valve
MH  - Aortic Valve Insufficiency/*physiopathology/surgery
MH  - Aortic Valve Stenosis/*physiopathology/surgery
MH  - Autonomic Nervous System/physiopathology
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart/innervation
MH  - Heart Rate/*physiology
MH  - Heart Valve Prosthesis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Signal Processing, Computer-Assisted
MH  - Time Factors
PMC - PMC6655940
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
PMCR- 2009/02/03
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PHST- 2009/02/03 00:00 [pmc-release]
AID - CLC4960200408 [pii]
AID - 10.1002/clc.4960200408 [doi]
PST - ppublish
SO  - Clin Cardiol. 1997 Apr;20(4):341-4. doi: 10.1002/clc.4960200408.