PMID- 9100217
OWN - NLM
STAT- MEDLINE
DCOM- 19970606
LR  - 20191210
IS  - 0731-5724 (Print)
IS  - 0731-5724 (Linking)
VI  - 16
IP  - 2
DP  - 1997 Apr
TI  - Evaluation of differential effects of carbohydrate and fat intake on weight gain, 
      serum IGF-1 and erythrocyte Na+K+ATPase activity in suboptimal nutrition in rats.
PG  - 159-65
AB  - OBJECTIVE: Suboptimal nutrition leads to growth delay, frequently without over 
      clinical or biochemical signs. We hypothesize that changes in serum IFG-1 and 
      erythrocyte sodium-potassium ATPase activity (ENKA) may be indices of suboptimal 
      nutrition. METHODS: Male Sprague-Dawley rats were pair-fed for 4 weeks with 
      balanced diets of different carbohydrate (CHO) to fat (FAT) ratios (3:1, 2:1, and 
      1:1) and three levels of energy intake (ad-libitum, 80%, and 60%), corrected for 
      actual body weight). Daily weight gain and weekly tail growth were monitored 
      while ENKA, serum total protein, T3, insulin and IGF-1 were measured after four 
      weeks. Refeeding experiments were also performed with the 3:1 and 1:1 CHO:FAT 
      diets, including 4 weeks of dietary restriction and one week of ad-libitum 
      feeding. RESULTS: Weight gain, tail growth, and IGF-1 decreased (p < 0.05) in all 
      groups after 1 week of dietary restriction. A decrease in ENKA (p < 0.05) was 
      found in rats that consumed 60% of ad-libitum energy intake only after 4 weeks. 
      At the end of dietary treatment, weight gain was higher (p < 0.05) in rats fed 
      the 3:1 CHO:FAT diet. In contrast, when energy was restricted to 80% or 60% of 
      ad-libitum intake, rats fed the 1:1 CHO:FAT diet gained more weight (p < 0.05) 
      compared to the 3:1 and 2:1 CHO:FAT diets. After 1 week of refeeding body weight, 
      tail growth and ENKA returned to control values while serum IGF-1 levels remained 
      depressed. CONCLUSIONS: Acute nutritional changes are clearly detected by a 
      reduction of serum IGF-1 while ENKA may be a useful index for assessing chronic 
      suboptimal nutrition.
FAU - Tarim, O
AU  - Tarim O
AD  - Department of Pediatrics, Maimonides Medical Center, Brooklyn, New York, USA.
FAU - Chasalow, F I
AU  - Chasalow FI
FAU - Murphy, J
AU  - Murphy J
FAU - Rising, R
AU  - Rising R
FAU - Carrillo, A
AU  - Carrillo A
FAU - Lifshitz, F
AU  - Lifshitz F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - *Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology
MH  - Dietary Fats/administration & dosage/*pharmacology
MH  - Energy Intake
MH  - Erythrocytes/*enzymology
MH  - Evaluation Studies as Topic
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium-Potassium-Exchanging ATPase/*blood
MH  - *Weight Gain
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1080/07315724.1997.10718667 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 1997 Apr;16(2):159-65. doi: 10.1080/07315724.1997.10718667.