PMID- 9100320
OWN - NLM
STAT- MEDLINE
DCOM- 19970714
LR  - 20191024
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 11
IP  - 2-3
DP  - 1997 Mar-Jun
TI  - New approaches for assessing the etiology and risks of developmental 
      abnormalities from chemical exposure.
PG  - 443-51
AB  - Developmental toxicants, insidious in modes of action and effects, strike the 
      very origin of our lives: the developing embryo, fetus, neonate, and child; they 
      cause spontaneous abortions, stillbirths, malformations, early postnatal 
      mortality, reduced birth weight, mental retardation, sensory loss as well as 
      other functional or physical changes, including subclinical effects having far 
      reaching social and economic impacts. The large majority of developmental defects 
      have unknown etiologies. With this uncertainty, EPA and the scientific community 
      world-wide give high priority to finding new approaches for assessing etiology 
      and risks of developmental effects. The United Nations Conference on Environment 
      and Development (UNCED) and Agenda 21 mobilized the international community to 
      focus on risks posed by chemicals in the environment, including developmental 
      risks. The international harmonization of test and risk assessment guidelines for 
      developmental effects are priorities. Lead, persistent organic pollutants (POPs), 
      endocrine disruptors, and the improvement of quantitative risk assessment 
      methodologies, particularly for children, are priorities. EPA reinvented its 
      research agenda of assure wide involvement of the National Science Foundation, 
      other federal agencies, and national experts in research to address the U.S.'s 
      public health and environmental priorities.
FAU - Goldman, L R
AU  - Goldman LR
AD  - Office of Prevention, Pesticides, and Toxic Substances, U.S. Environmental 
      Protection Agency, Washington, D.C.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Teratogens)
SB  - IM
MH  - Abnormalities, Drug-Induced/*etiology
MH  - Child
MH  - Developmental Disabilities/*etiology
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Humans
MH  - International Cooperation
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Research
MH  - Risk
MH  - Risk Assessment
MH  - Teratogens/*toxicity
MH  - United States
MH  - United States Environmental Protection Agency
RF  - 62
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1016/s0890-6238(96)00159-1 [doi]
PST - ppublish
SO  - Reprod Toxicol. 1997 Mar-Jun;11(2-3):443-51. doi: 10.1016/s0890-6238(96)00159-1.