PMID- 9103196
OWN - NLM
STAT- MEDLINE
DCOM- 19970502
LR  - 20230411
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 276
IP  - 5311
DP  - 1997 Apr 18
TI  - Positional cloning of the gene for multiple endocrine neoplasia-type 1.
PG  - 404-7
AB  - Multiple endocrine neoplasia-type 1 (MEN1) is an autosomal dominant familial 
      cancer syndrome characterized by tumors in parathyroids, enteropancreatic 
      endocrine tissues, and the anterior pituitary. DNA sequencing from a previously 
      identified minimal interval on chromosome 11q13 identified several candidate 
      genes, one of which contained 12 different frameshift, nonsense, missense, and 
      in-frame deletion mutations in 14 probands from 15 families. The MEN1 gene 
      contains 10 exons and encodes a ubiquitously expressed 2.8-kilobase transcript. 
      The predicted 610-amino acid protein product, termed menin, exhibits no apparent 
      similarities to any previously known proteins. The identification of MEN1 will 
      enable improved understanding of the mechanism of endocrine tumorigenesis and 
      should facilitate early diagnosis.
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
AD  - Laboratory of Gene Transfer, National Human Genome Research Institute (NHGRI), 
      National Institutes of Health (NIH), Bethesda, MD 20892, USA.
FAU - Guru, S C
AU  - Guru SC
FAU - Manickam, P
AU  - Manickam P
FAU - Olufemi, S E
AU  - Olufemi SE
FAU - Collins, F S
AU  - Collins FS
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Debelenko, L V
AU  - Debelenko LV
FAU - Zhuang, Z
AU  - Zhuang Z
FAU - Lubensky, I A
AU  - Lubensky IA
FAU - Liotta, L A
AU  - Liotta LA
FAU - Crabtree, J S
AU  - Crabtree JS
FAU - Wang, Y
AU  - Wang Y
FAU - Roe, B A
AU  - Roe BA
FAU - Weisemann, J
AU  - Weisemann J
FAU - Boguski, M S
AU  - Boguski MS
FAU - Agarwal, S K
AU  - Agarwal SK
FAU - Kester, M B
AU  - Kester MB
FAU - Kim, Y S
AU  - Kim YS
FAU - Heppner, C
AU  - Heppner C
FAU - Dong, Q
AU  - Dong Q
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Burns, A L
AU  - Burns AL
FAU - Marx, S J
AU  - Marx SJ
LA  - eng
SI  - GENBANK/U93236
SI  - GENBANK/U93237
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA, Complementary)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - *Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Exons
MH  - Frameshift Mutation
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation
MH  - Neoplasm Proteins/chemistry/*genetics
MH  - *Proto-Oncogene Proteins
EDAT- 1997/04/18 00:00
MHDA- 1997/04/18 00:01
CRDT- 1997/04/18 00:00
PHST- 1997/04/18 00:00 [pubmed]
PHST- 1997/04/18 00:01 [medline]
PHST- 1997/04/18 00:00 [entrez]
AID - 10.1126/science.276.5311.404 [doi]
PST - ppublish
SO  - Science. 1997 Apr 18;276(5311):404-7. doi: 10.1126/science.276.5311.404.