PMID- 9105097
OWN - NLM
STAT- MEDLINE
DCOM- 19970507
LR  - 20041117
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 155
IP  - 4
DP  - 1997 Apr
TI  - Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis 
      patients.
PG  - 1474-7
AB  - In pulmonary tuberculosis, the proportion of lymphocytes, particularly that of 
      CD4+ T lymphocytes, was increased in bronchoalveolar lavage fluid (BALF), 
      reflecting their protective role against mycobacterial infections. In order to 
      elucidate the mechanisms of lymphocyte accumulation in lungs, we measured the 
      levels of chemokines with potent lymphocyte chemotactic activities, including 
      interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and, regulated 
      on activation, normal T-cell expressed and secreted (RANTES) present in BALF from 
      patients with pulmonary tuberculosis in acute (n = 10) and convalescent phases (n 
      = 6), as well as normal subjects (n = 10). During the acute phase of the disease, 
      the proportions of lymphocytes and neutrophils were increased, as reported in 
      previous studies. The levels of IL-8, MCP-1, and RANTES in the acute phase of 
      pulmonary tuberculosis were also markedly elevated as compared with those of 
      normal subjects. MCP-1 and RANTES, but not IL-8 levels present in BALF, decreased 
      in the convalescent phase. Moreover, the concentration of RANTES correlated 
      significantly with the absolute number of CD4+ cells in BALF. These data suggest 
      that chemotactic cytokines are differentially produced and participate in the 
      host response to Mycobacterium tuberculosis infection.
FAU - Kurashima, K
AU  - Kurashima K
AD  - Third Department of Internal Medicine, School of Medicine, Kanazawa University, 
      Japan.
FAU - Mukaida, N
AU  - Mukaida N
FAU - Fujimura, M
AU  - Fujimura M
FAU - Yasui, M
AU  - Yasui M
FAU - Nakazumi, Y
AU  - Nakazumi Y
FAU - Matsuda, T
AU  - Matsuda T
FAU - Matsushima, K
AU  - Matsushima K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Chemokines)
SB  - IM
MH  - Bronchoalveolar Lavage Fluid/*chemistry/cytology
MH  - CD4 Lymphocyte Count
MH  - Case-Control Studies
MH  - Cell Count
MH  - Chemokines/*analysis
MH  - Humans
MH  - Lymphocytes/cytology
MH  - Mycobacterium tuberculosis/immunology
MH  - Neutrophils/cytology
MH  - Tuberculosis, Pulmonary/diagnosis/immunology/*metabolism
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1164/ajrccm.155.4.9105097 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1997 Apr;155(4):1474-7. doi: 
      10.1164/ajrccm.155.4.9105097.