PMID- 9107416
OWN - NLM
STAT- MEDLINE
DCOM- 19970623
LR  - 20190905
IS  - 0300-5208 (Print)
IS  - 0300-5208 (Linking)
VI  - 204
DP  - 1997
TI  - Dendritic cells and T lymphocytes: developmental and functional interactions.
PG  - 130-8; discussion 138-41
AB  - Dendritic cells (DCs) are specialized for presentation of antigen to T cells and 
      are essential for primary T cell activation. Although DCs are generally 
      considered to be myeloid derived, we now have evidence that a subgroup are of 
      lymphoid origin. In particular, the DCs of the adult mouse thymus appear to be 
      derived from the same early, lymphoid-restricted precursor cells that generate T 
      lymphocytes. Purified early thymic T precursors have the capacity to produce T 
      cells, B cells, NK cells and DCs, but not myeloid cells, on transfer to 
      irradiated recipients. They also produce thymic DCs on culture with a mix of 
      cytokines; this mix does not include GM-CSF, needed to generate myeloid-derived 
      DCs. A subgroup of DCs in other lymphoid organs, which like thymic DCs express 
      CD8 as an alpha alpha homodimer, may likewise be of lymphoid origin. These CD8+ 
      DCs in mouse spleen differ functionally from the conventional CD8+ DCs. CD8+ DCs 
      efficiently activate CD4+ T cells but then kill them via Fas ligand on the DC 
      surface. CD8+ DCs efficiently recruit CD8+ T cells into the cell cycle, but their 
      proliferation is then restricted by an inadequate production of interleukin 2. 
      This subgroup of CD8+ DCs therefore appears to have a regulatory role.
FAU - Shortman, K
AU  - Shortman K
AD  - Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, 
      Victoria, Australia.
FAU - Wu, L
AU  - Wu L
FAU - Suss, G
AU  - Suss G
FAU - Kronin, V
AU  - Kronin V
FAU - Winkel, K
AU  - Winkel K
FAU - Saunders, D
AU  - Saunders D
FAU - Vremec, D
AU  - Vremec D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Ciba Found Symp
JT  - Ciba Foundation symposium
JID - 0356636
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
MH  - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
MH  - Immunity, Cellular
MH  - Immunophenotyping
MH  - Lymphocyte Activation
MH  - Mice
MH  - Spleen/cytology
MH  - T-Lymphocytes/*immunology
MH  - Thymus Gland/cytology
RF  - 20
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/9780470515280.ch9 [doi]
PST - ppublish
SO  - Ciba Found Symp. 1997;204:130-8; discussion 138-41. doi: 
      10.1002/9780470515280.ch9.