PMID- 9109937
OWN - NLM
STAT- MEDLINE
DCOM- 19970501
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 94
IP  - 2
DP  - 1997 Apr
TI  - Detection of trisomy 8 using conventional cytogenetic techniques and interphase 
      FISH analysis in 34 myeloid disorders: a comparative study.
PG  - 103-5
AB  - Trisomy for chromosome 8 is one of the most common chromosome abnormalities 
      detected in myeloid disorders. However, and despite its great incidence, its 
      biologic significance remains poorly understood. Recently, some reports have 
      shown the existence of masked trisomy 8 in myeloid disorders. To try to detect 
      occult trisomy 8, we performed a study in which 34 myeloid disorders with 
      apparent normal karyotypes using conventional cytogenetic techniques were 
      analyzed using fluorescence in situ hybridization (FISH) analysis. Masked trisomy 
      8 was not detected in any of the 34 cases studied. This suggests that trisomy 8 
      may be a rare event in myeloid disorders in which an optimal conventional 
      cytogenetic analysis has been performed. The acquisition of trisomy 8 either in 
      early neoplastic stages in some cases or in late neoplastic stages in others and 
      the absence of masked trisomy 8 suggest that this chromosome alteration may not 
      be essential to the development of myeloid disorders.
FAU - Arranz, E
AU  - Arranz E
AD  - Department of Genetics, Fundacion Jimenez Diaz, Madrid, Spain.
FAU - Robledo, M
AU  - Robledo M
FAU - Martinez, B
AU  - Martinez B
FAU - Prieto, E
AU  - Prieto E
FAU - Portero, J A
AU  - Portero JA
FAU - Benitez, J
AU  - Benitez J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Bone Marrow/pathology
MH  - *Chromosomes, Human, Pair 8
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Interphase
MH  - Myelodysplastic Syndromes/*genetics/pathology
MH  - Trisomy/*diagnosis
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - S0165-4608(96)00208-7 [pii]
AID - 10.1016/s0165-4608(96)00208-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Apr;94(2):103-5. doi: 10.1016/s0165-4608(96)00208-7.