PMID- 9110150
OWN - NLM
STAT- MEDLINE
DCOM- 19970724
LR  - 20061115
IS  - 1148-5493 (Print)
IS  - 1148-5493 (Linking)
VI  - 8
IP  - 1
DP  - 1997 Mar
TI  - Transient rise in serum cytokines during coronary artery bypass graft surgery.
PG  - 61-6
AB  - In order to examine the specificity of cytokine production during coronary artery 
      bypass graft (CABG) surgery, we serially measured serum levels of monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), interleukin-6 (IL-6), 
      interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF), in twenty 
      patients between 52 and 80 years of age, during surgery and 2 days afterwards. 
      Serum MCP-1, as well as IL-8 and IL-6, increased significantly during the surgery 
      (P < 0.05), while IL-1 beta and TNF did not. MCP-1, IL-8 and IL-6 concentrations 
      were not different in the sera of three patients tested at three different sites, 
      i.e., the hepatic vein, pulmonary artery and radial artery. They increased in 
      parallel in each patient, although the actual timing of the increase relative to 
      the surgical step varied among individuals. In complicated patients, MCP-1, IL-8 
      and IL-6 showed higher peaks and persisted longer than in patients without 
      complications. The universal and simultaneous appearance of MCP-1, IL-8 and IL-6 
      could indicate that these three cytokines may be stimulated by a yet undiscovered 
      stimulus (or stimuli) which occurs systemically despite the independent pathways 
      of production.
FAU - Fujiwara, T
AU  - Fujiwara T
AD  - Department of Anesthesia and Intensive Care, Omiya Medical Center, Jichi Medical 
      School, Japan.
FAU - Seo, N
AU  - Seo N
FAU - Murayama, T
AU  - Murayama T
FAU - Hirata, S
AU  - Hirata S
FAU - Kawahito, K
AU  - Kawahito K
FAU - Kawakami, M
AU  - Kawakami M
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur Cytokine Netw
JT  - European cytokine network
JID - 9100879
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CCL2/*blood
MH  - *Coronary Artery Bypass
MH  - Humans
MH  - Interleukins/*blood
MH  - Intraoperative Period
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
PST - ppublish
SO  - Eur Cytokine Netw. 1997 Mar;8(1):61-6.