PMID- 9111765
OWN - NLM
STAT- MEDLINE
DCOM- 19970512
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 180
IP  - 2
DP  - 1996 Oct
TI  - Enhancing the effect of anticancer drugs against the colorectal cancer cell line 
      with electroporation.
PG  - 161-71
AB  - Electroporation was applied in vitro and in vivo in the treatment of human 
      colorectal cancer cell lines to study whether it can enhance the effect of 
      bleomycin (BLM), 5-fluorouracil (5-FU) and cis-platinum (CDDP). We used LS174T 
      and Colo320 cells derived from human colon cancer as target cells in this study. 
      When the LS174T cells were used as target cells, the IC50 of BLM decreased to 
      10(-3) times, while that of 5-FU decreased to only about one fifth with the 
      application of electric current. In the case of the Colo320 cells, the IC50 of 
      BLM and 5-FU were about one hundredth and a half, respectively. The effect of 
      CDDP was not enhanced with electric current. In vivo experiments were also 
      performed using LS174T cells transplanted subcutaneously (s.c.) into nude mice. 
      By treatment with intravenously (i.v.) administered BLM and simultaneous 
      application of the electric current, tumors were markedly decreased in size after 
      three weeks.
FAU - Kambe, M
AU  - Kambe M
AD  - Department of Clinical Oncology, Tohoku University, Sendai.
FAU - Arita, D
AU  - Arita D
FAU - Kikuchi, H
AU  - Kikuchi H
FAU - Funato, T
AU  - Funato T
FAU - Tezuka, F
AU  - Tezuka F
FAU - Gamo, M
AU  - Gamo M
FAU - Murakawa, Y
AU  - Murakawa Y
FAU - Kanamaru, R
AU  - Kanamaru R
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Antineoplastic Agents)
RN  - 11056-06-7 (Bleomycin)
RN  - Q20Q21Q62J (Cisplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use/*toxicity
MH  - Bleomycin/therapeutic use/toxicity
MH  - Cell Division/drug effects
MH  - Cisplatin/therapeutic use/toxicity
MH  - Colorectal Neoplasms/*drug therapy/pathology
MH  - *Electroporation
MH  - Fluorouracil/therapeutic use/toxicity
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Transplantation, Heterologous
MH  - Tumor Cells, Cultured
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 10.1620/tjem.180.161 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 1996 Oct;180(2):161-71. doi: 10.1620/tjem.180.161.