PMID- 9112469
OWN - NLM
STAT- MEDLINE
DCOM- 19970508
LR  - 20190708
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 37
IP  - 3
DP  - 1997 Feb 1
TI  - Automated planning target volume generation: an evaluation pitting a 
      computer-based tool against human experts.
PG  - 697-704
AB  - PURPOSE: Software tools are seeing increased use in three-dimensional treatment 
      planning. However, the development of these tools frequently omits careful 
      evaluation before placing them in clinical use. This study demonstrates the 
      application of a rigorous evaluation methodology using blinded peer review to an 
      automated software tool that produces ICRU-50 planning target volumes (PTVs). 
      METHODS AND MATERIALS: Seven physicians from three different institutions 
      involved in three-dimensional treatment planning participated in the evaluation. 
      Four physicians drew partial PTVs on nine test cases, consisting of four 
      nasopharynx and five lung primaries. Using the same information provided to the 
      human experts, the computer tool generated PTVs for comparison. The remaining 
      three physicians, designated evaluators, individually reviewed the PTVs for 
      acceptability. To exclude bias, the evaluators were blinded to the source (human 
      or computer) of the PTVs they reviewed. Their scorings of the PTVs were 
      statistically examined to determine if the computer tool performed as well as the 
      human experts. RESULTS: The computer tool was as successful as the human experts 
      in generating PTVs. Failures were primarily attributable to insufficient margins 
      around the clinical target volume and to encroachment upon critical structures. 
      In a qualitative analysis, the human and computer experts displayed similar types 
      and distributions of errors. CONCLUSIONS: Rigorous evaluation of computer-based 
      radiotherapy tools requires comparison to current practice and can reveal areas 
      for improvement before the tool enters clinical practice.
FAU - Ketting, C H
AU  - Ketting CH
AD  - Department of Radiation Medicine, Loma Linda University Medical Center, CA, USA.
FAU - Austin-Seymour, M
AU  - Austin-Seymour M
FAU - Kalet, I
AU  - Kalet I
FAU - Jacky, J
AU  - Jacky J
FAU - Kromhout-Schiro, S
AU  - Kromhout-Schiro S
FAU - Hummel, S
AU  - Hummel S
FAU - Unger, J
AU  - Unger J
FAU - Fagan, L M
AU  - Fagan LM
FAU - Griffin, T
AU  - Griffin T
LA  - eng
GR  - LM04174-08/LM/NLM NIH HHS/United States
GR  - N01-CM97566/CM/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - *Expert Systems
MH  - Humans
MH  - Lung Neoplasms/radiotherapy
MH  - Nasopharyngeal Neoplasms/radiotherapy
MH  - Observer Variation
MH  - *Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Regression Analysis
MH  - Reproducibility of Results
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - S0360301696005627 [pii]
AID - 10.1016/s0360-3016(96)00562-7 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 1997 Feb 1;37(3):697-704. doi: 
      10.1016/s0360-3016(96)00562-7.