PMID- 9112974
OWN - NLM
STAT- MEDLINE
DCOM- 19970502
LR  - 20081121
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 38
IP  - 5
DP  - 1997 Apr
TI  - Acute effects of blood glucose on chromatic visually evoked potentials in persons 
      with diabetes and in normal persons.
PG  - 800-10
AB  - PURPOSE: To determine whether specific chromatic pathways are selectively 
      affected by short-term variations in blood glucose levels in observers with and 
      without diabetes. METHODS: Ten subjects with diabetes, all with type 1 diabetes 
      and no retinopathy, and eight age-similar normal subjects were tested. Cortical 
      visually evoked potentials (VEPs) in response to stimuli designed to selectively 
      activate the short-wavelength-sensitive (S) or long- and 
      middle-wavelength-sensitive (LM) chromatic (isoluminant) pathways or the 
      achromatic pathway were recorded over a period of several hours. Capillary blood 
      glucose also was measured repeatedly over the same period. The relation between 
      VEP latency and blood glucose was determined. RESULTS: The S-pathway VEP latency 
      was correlated significantly with blood glucose in a slight majority (6/10) of 
      persons with diabetes; S-pathway latency was longer at higher blood glucose 
      levels. This association between S-pathway latency and blood glucose was not 
      dependent on the pattern of blood glucose variation over time (i.e., significant 
      correlations between blood glucose and latency were observed in persons for whom 
      blood glucose increased, decreased, or rose and then fell over time). No 
      dependence on blood glucose was observed for LM- or achromatic-pathway VEP 
      latency in subjects with diabetes. CONCLUSIONS: Acute variations in blood glucose 
      of subjects with diabetes over hours selectively affect the function of the 
      short-wavelength-sensitive chromatic pathway. The findings are discussed within 
      the context of known mechanisms by which elevated glucose affects cellular 
      metabolism with a time course consistent with the transient nature of the effect 
      observed.
FAU - Schneck, M E
AU  - Schneck ME
AD  - School of Optometry, University of California at Berkeley 94720-2020, USA.
FAU - Fortune, B
AU  - Fortune B
FAU - Switkes, E
AU  - Switkes E
FAU - Crognale, M
AU  - Crognale M
FAU - Adams, A J
AU  - Adams AJ
LA  - eng
GR  - EY02271/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*physiology
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Cone Photoreceptor Cells/*physiopathology
MH  - Visual Pathways/physiopathology
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 1997 Apr;38(5):800-10.