PMID- 9113276
OWN - NLM
STAT- MEDLINE
DCOM- 19970722
LR  - 20131121
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 21
IP  - 2
DP  - 1997 Apr
TI  - Repeated exposure to moderate doses of alcohol in the rat fetus: evidence of 
      sensitization to toxic and chemosensory aspects of alcohol.
PG  - 360-7
AB  - Two experiments tested responsiveness of the rat fetus to alcohol on gestational 
      day (GD) 20 after previous maternal administration of low-to-moderate doses of 
      alcohol (1 or 2 g/kg during GDs 17 to 19). Maternal alcohol intoxication on GD 20 
      resulted in substantial suppression of spontaneous fetal motor activity. The 
      analysis of mouthing movements showed that this suppression of movement was 
      further enhanced by exposure to alcohol during the previous 3 days of gestation 
      (GDs 17 to 19). A second experiment indicated that this same exposure to alcohol 
      during GDs 17 to 19 induced fetuses on GD 20 to emit more mouthing movements in 
      response to intraoral infusions of alcohol. A moderate amount of prenatal alcohol 
      exposure apparently sensitizes the fetus to the pharmacological and orosensory 
      effects of alcohol.
FAU - Chotro, M G
AU  - Chotro MG
AD  - Center for Developmental Psychobiology, Binghamton University, New York 
      13902-6000, USA.
FAU - Spear, N E
AU  - Spear NE
LA  - eng
GR  - 1RO1AA102230/AA/NIAAA NIH HHS/United States
GR  - 5RO1AA06634/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Ethanol/*toxicity
MH  - Fetal Alcohol Spectrum Disorders/*physiopathology
MH  - Fetal Movement/drug effects/physiology
MH  - Gestational Age
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taste/*drug effects/physiology
MH  - Taste Buds/*drug effects/physiopathology
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 00000374-199704000-00027 [pii]
PST - ppublish
SO  - Alcohol Clin Exp Res. 1997 Apr;21(2):360-7.