PMID- 9116231
OWN - NLM
STAT- MEDLINE
DCOM- 19970418
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 7
IP  - 18
DP  - 1996 Nov 25
TI  - Reduced CaMKII-positive neurones in the accumbens shell of an animal model of 
      attention-deficit hyperactivity disorder.
PG  - 3017-20
AB  - THIS study aimed at investigating putative neural substrates of attention-deficit 
      hyperactivity disorder in children using the spontaneously hypertensive rat (SHR) 
      as animal model and the Ca2+/calmodulin-dependent protein kinase II (CaMKII) as a 
      marker in the nucleus accumbens, an interface between limbic and motor systems. 
      In prehypertensive male SHR and Wistar-Kyoto rats image analysis of CaMKII 
      immunocytochemistry showed more positive elements in the shell than in the core, 
      and in the former a lower level in SHR. The data indicate a reduced number of 
      nucleus accumbens modules available for limbic-motor integration revealing 
      putative substrates of the altered attentional and reinforcement mechanisms 
      demonstrated in the SHR and in children with attention-deficit hyperactivity 
      disorder.
FAU - Papa, M
AU  - Papa M
AD  - Institute of Human Anatomy, Second University of Naples (SUN), Italy.
FAU - Sagvolden, T
AU  - Sagvolden T
FAU - Sergeant, J A
AU  - Sergeant JA
FAU - Sadile, A G
AU  - Sadile AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Isoenzymes)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Attention/physiology
MH  - Attention Deficit Disorder with Hyperactivity/*enzymology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/biosynthesis/*metabolism
MH  - Immunohistochemistry
MH  - Isoenzymes/biosynthesis/*metabolism
MH  - Male
MH  - Neurons/*enzymology
MH  - Nucleus Accumbens/cytology/*enzymology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1996/11/25 00:00
MHDA- 2000/03/23 09:00
CRDT- 1996/11/25 00:00
PHST- 1996/11/25 00:00 [pubmed]
PHST- 2000/03/23 09:00 [medline]
PHST- 1996/11/25 00:00 [entrez]
AID - 10.1097/00001756-199611250-00044 [doi]
PST - ppublish
SO  - Neuroreport. 1996 Nov 25;7(18):3017-20. doi: 10.1097/00001756-199611250-00044.