PMID- 9118204
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20191024
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 17
IP  - 1
DP  - 1997 Feb
TI  - Modulation of phosphorylation of neuronal cytoskeletal proteins by neuronal 
      depolarization.
PG  - 129-40
AB  - 1. The neuronal cytoskeletal protein tau and the carboxy tails of cytoskeletal 
      proteins neurofilament-M (NF-M) and neurofilament-H (NF-H) are phosphorylated on 
      serine residues by the cyclin-dependent kinase cdk-5. 2. In aggregating 
      neuronal-glial cultures we show that veratridine-mediated cation influx causes 
      dephosphorylation of tau, NF-M and NF-H. Dephosphorylation was blocked 
      specifically by cyclosporine A but not by okadiac acid at concentrations up to 
      200 nM. 3. These results suggest that veratridine-triggered cation influx causes 
      activation of PP-2B (calcineurin) leading to dephosphorylation of these 
      cytoskeletal proteins.
FAU - Mata, M
AU  - Mata M
AD  - Department of Neurology, University of Pittsburgh, Pennsylvania, USA.
FAU - Honegger, P
AU  - Honegger P
FAU - Fink, D J
AU  - Fink DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (Neuromuscular Depolarizing Agents)
RN  - 0 (tau Proteins)
RN  - 71-62-5 (Veratridine)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Cells, Cultured
MH  - Cytoskeletal Proteins/drug effects/*metabolism
MH  - Embryo, Mammalian
MH  - Nerve Tissue Proteins/drug effects/*metabolism
MH  - Neurofilament Proteins/drug effects/*metabolism
MH  - Neuromuscular Depolarizing Agents/pharmacology
MH  - Phosphoric Monoester Hydrolases/drug effects/*physiology
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Sodium/metabolism
MH  - Veratridine/pharmacology
MH  - tau Proteins/metabolism
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1023/a:1026337322916 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 1997 Feb;17(1):129-40. doi: 10.1023/a:1026337322916.